The Synthetic Routes of 3-Pyridinamine, 2-methoxy-N-(1-methylethyl)-

3-Pyridinamine is a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products.
One of the most common methods of synthesizing 3-pyridinamine involves the use of a synthetic route that involves several steps and various chemical reactions.
The synthetic route typically begins with the synthesis of a starting material, such as 2-methoxy-N-(1-methylethyl)acetamide, which is then transformed into 3-pyridinamine through a series of chemical reactions.

The synthetic route to 3-pyridinamine typically begins with the reaction of acetyl chloride with S-2-methylthiopropionyl chloride in the presence of a solvent such as DCM to obtain S-2-methylthiopropionyl acetate.
This compound is then reduced to S-2-methylthiopropionyl amine using hydrogen in the presence of a catalyst such as palladium on barium sulfate.

Next, the S-2-methylthiopropionyl amine is transformed into N-(1-methoxy-2-methyl ethyl) acetamide through the reaction with acetic anhydride in the presence of a solvent such as DMF.
This intermediate is then hydrolyzed using a base such as sodium hydroxide in the presence of a solvent such as ethanol to obtain N-(1-methoxy-2-methyl ethyl)amine.

The next step in the synthetic route to 3-pyridinamine is the reaction of N-(1-methoxy-2-methyl ethyl)amine with chloroacetic acid in the presence of a solvent such as DCM to obtain N-(1-methoxy-2-methyl ethyl)-2-chloroacetamide.
This compound is then transformed into N-(1-methoxy-2-methyl ethyl)-2-methoxy-N-(1-methylethyl) acetamide through the reaction with N-(1-methoxy-2-methyl ethyl)amine in the presence of a solvent such as DMF.

Finally, the N-(1-methoxy-2-methyl ethyl)-2-methoxy-N-(1-methylethyl) acetamide is hydrolyzed using a base such as sodium hydroxide in the presence of a solvent such as ethanol to obtain 3-pyridinamine.

The synthetic route to 3-pyridinamine described above is just one example of the many synthetic routes that can be used to synthesize this compound.
Variations on this route can be used to optimize the synthesis for specific applications or to synthesize the compound on a larger scale.

Overall, the synthetic routes to 3-pyridinamine are diverse and can involve a variety of chemical reactions and transformations.
The choice of route will depend on the specific application and the desired properties of the final product.
However, the synthetic routes to 3-pyridinamine have proven to be effective and are widely used in the chemical industry for the synthesis of various chemical products.