The Synthetic Routes of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester

3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester, commonly referred to as 3-Pyridazinecarboxylic acid, 6-chloro-1-methylethyl ester, is an organic compound that is widely used in various industrial applications.
The compound is synthesized through several chemical routes, which can be broadly classified into two categories: synthetic routes and natural routes.
In this article, we will discuss the synthetic routes of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester.

The most commonly used synthetic route for the production of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester involves the reaction of 3-pyridazinecarboxylic acid chloride with 1-methylethyl alcohol in the presence of a base catalyst such as sodium hydroxide.
The reaction occurs in several stages, with the first stage involving the formation of an intermediate carbocation, which undergoes nucleophilic attack by the alcohol to form an alcoholate.
The alcoholate then undergoes a series of steps, including hydrolysis and dehydration, to form the desired ester.
The reaction is typically carried out in a polar protic solvent such as water or a mixture of water and a polar organic solvent such as acetonitrile or DMF.

Another synthetic route for the production of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester involves the reaction of 3-pyridazinecarboxylic acid with 6-chloro-1-methylethylslane in the presence of a Lewis acid catalyst such as aluminum chloride.
The reaction occurs through a series of steps, including the formation of a carbocation intermediate, followed by nucleophilic attack by the slane and subsequent dehydration to form the desired ester.
The reaction is typically carried out in a polar protic solvent such as water or a mixture of water and a polar organic solvent such as acetonitrile or DMF.

Yet another synthetic route for the production of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester involves the reaction of 3-pyridazinecarboxylic acid with 1-methylethyl isocyanate in the presence of a catalyst such as K2CO3.
The reaction occurs through a series of steps, including the formation of an intermediate imine, followed by decarboxylation to form the desired amide, which is then hydrolyzed to form the desired ester.
The reaction is typically carried out in a polar aprotic solvent such as DMF or DMA.

The natural route for the production of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester involves the extraction of the compound from plants of the Apiaceaebitril, commonly known as celery or celeriac, which are rich in natural compounds.
The compound can be extracted using various solvents such as ethanol, methanol, or acetone, and the extracted compound can be purified using various techniques such as crystallization, chromatography, or recrystallization.

Overall, the synthetic routes of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester are relatively simple and involve the use of commonly available chemicals and reagents.
The choice of synthetic route depends on various factors such as the scale of production, the cost of raw materials, and the availability of the required equipment and facilities.
The natural route for the production of the compound