The Synthetic Routes of 3-PYRIDAZINECARBOXYLIC ACID, 6-AMINO-, ETHYL ESTER

3-Pyridazinedicarboxylic acid, 6-amino-, ethyl ester is an important intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products.
Its synthetic routes have been extensively studied, and there are several methods available to synthesize this compound.

One of the most common methods for synthesizing 3-pyridazinedicarboxylic acid, 6-amino-, ethyl ester involves the reaction of 6-aminonicotinic acid with ethyl 3-oxobutyrate using a condensation reaction.
The reaction typically takes place in the presence of a condensing agent, such as dicyclohexylcarbodiimide (DCC), hydrochloric acid, and 1,4-dioxane.
The product is then isolated by dissolving the crude reaction mixture in ethyl acetate and washing with water and brine.
The organic layer is then dried over anhydrous sodium sulfate, filtered, and concentrated to obtain the desired product.

Another synthetic route for 3-pyridazinedicarboxylic acid, 6-amino-, ethyl ester involves the reaction of ethyl 3-oxobutyrate with 6-aminonicotinic acid hydrochloride in the presence of a catalytic amount of pyridine.
The product is then isolated by precipitating the product with ethyl acetate, filtering, and washing with ethanol.
The precipitated product is then recrystallized from ethyl acetate-hexane to obtain the pure product.

A third synthetic route for 3-pyridazinedicarboxylic acid, 6-amino-, ethyl ester involves the reaction of ethyl 3-oxobutyrate with 6-aminonicotinic acid in the presence of a strong acid catalyst, such as sulfuric acid.
The product is then isolated by neutralizing the reaction mixture with sodium bicarbonate and extracting the product with ethyl acetate.
The organic layer is then washed with water and brine, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain the desired product.

In conclusion, there are several synthetic routes available for the synthesis of 3-pyridazinedicarboxylic acid, 6-amino-, ethyl ester.
The choice of route will depend on the availability of reagents, the scale of production, and the purity of the desired product.
Regardless of the route chosen, proper safety precautions should be taken to handle the reagents and products, as many of them are toxic or hazardous.
It is also important to follow proper disposal procedures to avoid environmental contamination.
With proper synthetic techniques and safety measures, 3-pyridazinedicarboxylic acid, 6-amino-, ethyl ester can be synthesized efficiently and cost-effectively for use in a variety of industrial and pharmaceutical applications.