The Synthetic Routes of 3-PHENYLISONICOTINIC ACID

The synthesis of 3-phenylimisonicotinic acid is an important process in the chemical industry, as this compound has a wide range of applications in various fields such as pharmaceuticals, agrochemicals, and cosmeceuticals.

There are several methods for the synthesis of 3-phenylimisonicotinic acid, and the choice of method depends on various factors such as the scale of production, the availability of starting materials, and the cost of the synthesis.

One of the most common methods for the synthesis of 3-phenylimisonicotinic acid is the Williamson ether synthesis.
In this method, phenyl magnesium bromide is reacted with sodium hydroxide to form a Grignard reagent, which is then treated with a halogen such as chlorine or bromine to form the ether.
The ether is then treated with a strong acid to form the carboxylic acid.

Another method for the synthesis of 3-phenylimisonicotinic acid is the synthesis using the Suzuki-Miyaura cross-coupling reaction.
In this method, a boronic acid is reacted with a phenylboronic acid and a palladium catalyst to form the cross-coupled product.
The cross-coupled product is then treated with a strong acid to form the carboxylic acid.

A third method for the synthesis of 3-phenylimisonicotinic acid is the synthesis using the Birch reduction.
In this method, a phenyl sulfide is treated with anhydrous aluminum chloride and sodium hydroxide to form a Grignard reagent, which is then treated with hydrogen chloride to form the carboxylic acid.

A fourth method for the synthesis of 3-phenylimisonicotinic acid is the synthesis using the hydrolysis of an alkyl or aryl halide.
In this method, an alkyl or aryl halide is treated with a strong acid to form the carboxylic acid.

A fifth method for the synthesis of 3-phenylimisonicotinic acid is the synthesis using the peroxide oxidation.
In this method, an alkyl or aryl alcohol is treated with hydrogen peroxide to form the carboxylic acid.

A sixth method for the synthesis of 3-phenylimisonicotinic acid is the synthesis using the oxidation of a primary or secondary alcohol.
In this method, a primary or secondary alcohol is treated with oxidizing agents such as sodium hydroxide, potassium permanganate, or chromic acid to form the carboxylic acid.

A seventh method for the synthesis of 3-phenylimisonicotinic acid is the synthesis using the reduction of an aldehyde with lithium aluminum hydride.
In this method, an aldehyde is treated with lithium aluminum hydride to form the carboxylic acid.

Overall, there are several syn