The Synthetic Routes of 3-Chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride, 98+% C9H13Cl2N3O, MW: 250.12

3-Chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride, also known as 98+% C9H13Cl2N3O, is a synthetic compound commonly used in the chemical industry.
With a molecular weight of 250.
12 and a theoretical formula of C9H13Cl2N3O, this compound is widely used in various applications, including pharmaceuticals, agrochemicals, and other industrial processes.

The synthetic routes for 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride can vary depending on the desired product specifications and the scale of production.
Here are some commonly used synthetic routes for this compound:

1. Direct amidation

Direct amidation is a common method for synthesizing 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride.
This involves the reaction of an amine, such as piperidine, with chloroacetyl chloride in the presence of a solvent, such as acetonitrile or DMF.
The reaction is typically carried out at room temperature and can be catalyzed by a base, such as sodium hydroxide.

2. Indirect amidation

Indirect amidation is another synthetic route for 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride.
In this method, a secondary amine is first synthesized, followed by the addition of chloroacetyl chloride to form the final product.
This route is useful when a high-purity product is required, as the secondary amine can be purified before the addition of chloroacetyl chloride.

3. Halogenation

Halogenation is another method for synthesizing 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride.
In this route, a primary amine is first synthesized, followed by halogenation with chlorine or bromine.
The reaction is typically carried out in the presence of a solvent, such as DMF or THF, and can be catalyzed by a base, such as sodium hydroxide.

4. Hydrochlorination

Hydrochlorination is another synthetic route for 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride.
In this route, a secondary or tertiary amine is first synthesized, followed by the addition of hydrogen chloride in the presence of a solvent, such as acetonitrile or DMF.
The reaction is typically carried out at room temperature and can be catalyzed by a base, such as sodium hydroxide.

5. Pethidine synthesis

Pethidine synthesis is a less common but useful synthetic route for 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride.
This involves the synthesis of pethidine, followed by the reaction of the pethidine with chloroacetyl chloride.
The reaction is typically carried out in the presence of a solvent, such as benzene or toluene, and can be catalyzed by a base, such as sodium acetate.

Overall, the choice of synthetic route for 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride will depend on various factors, including the desired product specifications, the scale of production, and the availability of starting materials and reagents.

In conclusion, 3-chloro-6-(piperidin-4-yloxy)-pyridazine hydrochloride is a versatile synthetic comp