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3-chloro-6-(3-(chloroMethyl)piperidin-1-yl)pyridazine is an important chemical compound that is widely used in the pharmaceutical and agrochemical industries.
It is a yellow or orange solid with a strong, unpleasant odor.
The molecular formula for this compound is C10H13Cl2N3, and it has a molecular weight of 246.
14.
The compound is a synthetic derivative of pyridazine and 3-chloro-6-(3-(chloroMethyl)piperidin-1-yl)pyridazine is commonly used as an intermediate in the production of other chemicals.
There are several different synthetic routes that can be used to produce 3-chloro-6-(3-(chloroMethyl)piperidin-1-yl)pyridazine, each with its own advantages and disadvantages.
The selection of a particular route will depend on a variety of factors, including the availability of starting materials, the desired yield and purity of the final product, and the cost and complexity of the synthesis.
One of the most common synthetic routes for 3-chloro-6-(3-(chloroMethyl)piperidin-1-yl)pyridazine involves a sequence of reactions that starts with the reaction of methyl iodide with 2,6-lutidine to form a Grignard reagent.
This Grignard reagent is then treated with 3-chloro-6-iodopyridazine in the presence of a base, such as sodium hydroxide, to form the desired compound.
Another synthetic route involves the reaction of 3-chloro-6-methylpyridazine with 3-chloro-6-(chloromethyl)piperidine in the presence of a strong acid catalyst, such as sulfuric acid.
This reaction can be carried out at room temperature and yields the desired compound in good yield.
A third synthetic route involves the reaction of 3-chloro-6-methylpyridazine with 3,3-dichloropropylamine in the presence of a base, such as triethylamine.
This reaction is then followed by the addition of chloroform and hydrazine to form the desired compound.
Overall, the synthetic routes for 3-chloro-6-(3-(chloroMethyl)piperidin-1-yl)pyridazine can be complex and require careful optimization of reaction conditions to achieve the desired yield and purity of the final product.
However, with the right approach, it is possible to synthesize this compound in a efficient and cost-effective manner.
