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3-Chloro-5-methylpyridazine is a compound that is widely used in various applications in the chemical industry.
It is an important intermediate in the production of a number of chemicals and pharmaceuticals and is also used as a catalyst and a solvent.
The synthetic routes for 3-chloro-5-methylpyridazine can be broadly classified into three categories: direct synthesis, indirect synthesis, and substitution reactions.
Direct synthesis refers to the synthesis of 3-chloro-5-methylpyridazine through a series of chemical reactions that involve the use of readily available starting materials.
One of the most common methods of direct synthesis is the reaction of 3-chloro-5-methylpyridazine with sodium hydroxide to form the base, which is then treated with a reactive halogen such as chlorine or bromine to form the corresponding halide.
This method is relatively simple and is widely used in the industry.
Indirect synthesis refers to the synthesis of 3-chloro-5-methylpyridazine through the use of intermediates that are then transformed into the final product.
One common method of indirect synthesis is the reaction of 5-methylpyridazine with chloroform to form 5-chloromethylpyridazine, which is then treated with sodium hydroxide to form the base.
This base is then treated with hydrochloric acid to form 3-chloro-5-methylpyridazine.
Substitution reactions refer to the synthesis of 3-chloro-5-methylpyridazine through the substitution of one atom or group of atoms in a parent compound with another atom or group of atoms.
One commonly used method of substitution reaction is the reaction of 3-methylpyridine with chloroform to form 3-chloromethylpyridine, which is then treated with sodium hydroxide to form the base.
This base is then treated with hydrochloric acid to form 3-chloro-5-methylpyridazine.
Overall, the synthetic routes for 3-chloro-5-methylpyridazine are varied and can be selected based on the availability of starting materials and the desired yield and purity of the final product.
The use of intermediates and substitution reactions can also result in the synthesis of other related compounds that may have useful applications in the chemical industry.
