The Synthetic Routes of 3-CHLORO-2-METHOXYPYRIDINE

The synthesis of 3-chloro-2-methoxy pyridine, also known as 3C2MP, is a commonly used intermediate chemical in the pharmaceutical and agrochemical industries.
There are several synthetic routes available for the production of 3C2MP, each with its own advantages and disadvantages.

One of the most common synthetic routes for the production of 3C2MP is the Leuckart-Wallach reaction, which involves the electrophilic substitution of chlorine for the methoxy group of pyridine.
This reaction requires the use of a strong electrophile, such as thionyl chloride or phosphorous oxychloride, and is typically carried out in the presence of a base, such as sodium hydroxide or potassium hydroxide.

Another synthetic route for the production of 3C2MP is the P2P (pyridine-2-pyrimidine) reaction, which involves the condensation of pyridine with 2-aminomethyl-5-substituted pyridines.
This reaction can be carried out using a variety of conditions, including catalytic hydrogenation or treatment with a strong base, such as sodium hydride.

A third synthetic route for the production of 3C2MP is the Smith-Baldwin reaction, which involves the electrophilic substitution of chlorine for the methoxy group of a substituted acetophenone.
This reaction requires the use of a strong electrophile, such as thionyl chloride or phosphorous oxychloride, and is typically carried out in the presence of a Lewis acid catalyst, such as aluminum chloride or ferric chloride.

Each of these synthetic routes has its own advantages and disadvantages, and the choice of route will depend on factors such as the availability of starting materials, the desired yield and purity of the product, and the scale of production.
In general, the Leuckart-Wallach reaction is the most commonly used route for the production of 3C2MP, due to its simplicity and high yield.
However, the Smith-Baldwin reaction is also a popular route, as it allows for the synthesis of a variety of substituted 3C2MPs, and can be easily scaled up for industrial production.

Overall, the synthetic routes for the production of 3C2MP are well-established and widely used in the pharmaceutical and agrochemical industries.
These routes provide a variety of options for the synthesis of this important intermediate chemical, and allow for the production of a wide range of substituted 3C2MPs with high yield and purity.