The Synthetic Routes of 3-AMINO-N-CYCLOHEXYLBENZENESULFONAMIDE

The Synthetic Routes of 3-Amino-N-Cyclohexybenzenesulfonamide: A Comprehensive Review in the Chemical Industry

Abstract:
3-Amino-N-cyclohexybenzenesulfonamide (CAS number: 11066-04-4) is a versatile organic compound with a wide range of applications in various industries, including pharmaceuticals, agrochemicals, and detergents.
The synthetic routes for this compound have been extensively researched in the chemical industry, with various methods and reagents being used to achieve the desired product.
This article provides a comprehensive review of the synthetic routes for 3-amino-N-cyclohexybenzenesulfonamide, including the classical methods, as well as the latest developments in the field.

Introduction:
3-Amino-N-cyclohexybenzenesulfonamide (CAS number: 11066-04-4), commonly referred to as SBS, is an organic compound with a wide range of applications in various industries.
It is an important intermediate in the synthesis of various chemicals, such as pharmaceuticals, agrochemicals, and detergents.
Due to its importance in various industrial applications, the synthetic routes for SBS have been extensively researched in the chemical industry.
This article provides a comprehensive review of the synthetic routes for SBS, including the classical methods and the latest developments in the field.

Classical Synthetic Routes:
The classical synthetic routes for SBS include the following:

1. Oxidation of cyclohexylbenzene: One of the most common methods for synthesizing SBS involves the oxidation of cyclohexylbenzene to generate the sulfonamide group.
   This method involves the use of reagents such as potassium permanganate, sodium hydroxide, and sodium sulfite to achieve the desired product.
   
2. Nitration of cyclohexylbenzene: Another common method for synthesizing SBS involves the nitration of cyclohexylbenzene to introduce the sulfonamide group.
   This method involves the use of reagents such as nitric acid, sulfuric acid, and sodium nitrate to achieve the desired product.
   
3. Reduction of nitrobenzene: Another route for synthesizing SBS involves the reduction of nitrobenzene to generate the sulfonamide group.
   This method involves the use of reagents such as hydrazine, sodium cyanide, and sodium hydroxide to achieve the desired product.
   

Newer Synthetic Routes:
In recent years, there have been several advances in the synthetic routes for SBS, including the following:

1. Direct sulfonation of cyclohexylbenzene: A more recent method for synthesizing SBS involves the direct sulfonation of cyclohexylbenzene using sulfuric acid.
   This method is more efficient than the traditional methods and does not require the use of nitric acid, which is a hazardous reagent.
   
2. Electrophilic substitution reaction: Another recent method for synthesizing SBS involves the use of electrophilic substitution reactions, such as the use of chloroformic acid, which has been shown to be an efficient and convenient method for introducing the sulfonamide group.
   
3. Polyoxometalate-catalyzed reaction: Polyoxometalates (POMs) have been used as catalysts in the synthesis of SBS, which has been shown to be a more efficient and environmentally friendly method compared to the traditional methods.
   

Conclusion:
In conclusion, the synthetic routes for 3-amino-N-cyclohexybenzenesulfonamide are diverse and have been extensively researched