The Synthetic Routes of 3-Amino-6-(propylthio)pyridazine

3-Amino-6-(propylthio)pyridazine is a synthetic compound that is widely used in the chemical industry.
This compound is used as a raw material in the production of various chemicals and pharmaceuticals.
In this article, we will discuss the synthetic routes of 3-amino-6-(propylthio)pyridazine.

Synthetic Route 1: via 2-thiopyridone
The first synthetic route to 3-amino-6-(propylthio)pyridazine involves the synthesis of 2-thiopyridone.
This is achieved by the reaction of 2-chinolinethanamine with propyl isothiocyanate in the presence of a solvent such as water or ethanol.
The product is then treated with hydrochloric acid to remove the isothiocyanate group, and then treated with sodium hydroxide to convert the 2-thiopyridone to 3-amino-6-(propylthio)pyridazine.

Synthetic Route 2: via 2-aminopyridine
Another synthetic route to 3-amino-6-(propylthio)pyridazine involves the synthesis of 2-aminopyridine.
This is achieved by the reaction of 2-ethylamino-5-propylpyridine with hydrogen sulfide in the presence of a solvent such as water or ethanol.
The product is then treated with sodium hydroxide to convert the 2-aminopyridine to 3-amino-6-(propylthio)pyridazine.

Synthetic Route 3: via 2-amino-5-propylpyridine
A third synthetic route to 3-amino-6-(propylthio)pyridazine involves the synthesis of 2-amino-5-propylpyridine.
This is achieved by the reaction of 2-ethylamino-5-propylpyridine with chloroacetyl chloride in the presence of a solvent such as dichloromethane.
The product is then treated with sodium hydroxide to convert the 2-amino-5-propylpyridine to 3-amino-6-(propylthio)pyridazine.

Advantages of Synthetic Routes

The synthetic routes to 3-amino-6-(propylthio)pyridazine offer several advantages over traditional synthetic methods.
Firstly, they involve the use of readily available starting materials, making them more cost-effective.
Secondly, they offer greater control over the reaction conditions, allowing for the production of high-purity products.
Thirdly, they are typically more environmentally friendly than traditional synthetic methods, as they involve the use of less hazardous chemicals.

Conclusion

3-Amino-6-(propylthio)pyridazine is an important synthetic compound that is widely used in the chemical industry.
There are several synthetic routes to this compound, each offering its own advantages.
These routes involve the use of readily available starting materials and offer greater control over the reaction conditions, allowing for the production of high-purity products.
Overall, the synthetic routes to 3-amino-6-(propylthio)pyridazine offer a convenient and cost-effective way to produce this important synthetic compound.