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The Synthetic Routes of 3-Amino-6-(ethylthio)pyridazine

 Last Update: 2023-05-08
 Source: Internet
 Author: User

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3-Amino-6-(ethylthio)pyridazine is an important intermediate in the synthesis of various chemicals and pharmaceuticals.
The following are some of the synthetic routes for this compound.

Reaction of 2-cyanopyridine with sodium ethylthiolate
One of the most common methods for synthesizing 3-amino-6-(ethylthio)pyridazine involves treating 2-cyanopyridine with sodium ethylthiolate in the presence of a solvent such as DMF.
The reaction begins by the formation of a thioacetal intermediate, which undergoes hydride transfer to generate the amine.
The resulting intermediate undergoes further reactions to form the final product.
Reaction of 2-bromopyridine with sodium hydrogensulfate
2-Bromopyridine can be treated with sodium hydrogensulfate in a solvent such as water to form 2-amino-5-bromopyridine.
This intermediate can then be treated with ethylthiol in the presence of a catalyst such as sodium hydroxide to form 3-amino-6-(ethylthio)pyridazine.
Reduction of 3-cyanopyridine with hydrogen in the presence of a reducing agent
3-Cy

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