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3-AcetaMido-4-Methylpyridazine is an important chemical compound that is commonly used in various industrial applications.
This compound can be synthesized through several different routes, including synthetic routes.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of 3-AcetaMido-4-Methylpyridazine.
One of the most commonly used synthetic routes for the synthesis of 3-AcetaMido-4-Methylpyridazine is the Lossen rearrangement of N-(2-chloropyridin-3-yl)acetamide.
This reaction is carried out by heating a mixture of N-(2-chloropyridin-3-yl)acetamide and sodium hydroxide in a suitable solvent, such as water or ethanol.
The reaction occurs in several steps, with the initial formation of an intermediate imine followed by rearrangement to produce 3-AcetaMido-4-Methylpyridazine.
Another commonly used synthetic route for the synthesis of 3-AcetaMido-4-Methylpyridazine is the nitration of pyrrole.
This reaction is carried out by treating a solution of pyrrole in a suitable solvent, such as acetonitrile or water, with a solution of nitric acid.
The reaction produces an intermediate nitro compound, which can then be treated with sodium cyanide to form 3-AcetaMido-4-Methylpyridazine.
A third synthetic route for the synthesis of 3-AcetaMido-4-Methylpyridazine is the reaction of 4-methylpyridine with acetyl chloride in the presence of a suitable catalyst, such as aluminum chloride.
This reaction occurs in several steps, with the initial formation of an intermediate imine followed by hydrolysis to produce 3-AcetaMido-4-Methylpyridazine.
In conclusion, there are several synthetic routes for the synthesis of 3-AcetaMido-4-Methylpyridazine, including the Lossen rearrangement of N-(2-chloropyridin-3-yl)acetamide, nitration of pyrrole, and reaction of 4-methylpyridine with acetyl chloride.
These routes provide a variety of methods for the synthesis of this important chemical compound, which is widely used in various industrial applications.
