The Synthetic Routes of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate

The Synthetic Routes of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate: A Comprehensive Review in the Chemical Industry

Abstract:

[3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate is a synthetic compound that has gained significant attention in recent years due to its unique properties and potential applications in a variety of industries, including pharmaceuticals, cosmetics, and materials science.
The synthesis of this compound involves several steps, which can be accomplished through different synthetic routes.
This article provides a comprehensive review of the synthetic routes available for the preparation of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate, including the classical methods as well as the latest advances in this field.

Introduction:

[3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate is a molecule with a unique structure, consisting of a combination of diverse functional groups that make it an attractive building block for the synthesis of various compounds.
The compound has been reported to exhibit anticancer, anti-inflammatory, and antibacterial activities, making it a promising candidate for the development of new drugs.
In addition, it can also be used as a raw material for the production of various materials, such as polymers and composites.
The synthesis of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate has been studied by several research groups around the world, leading to the development of various synthetic routes.

Classical Synthetic Routes:

The classical synthetic routes for the preparation of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate include the following:

1. Hydrolysis of Acetoxyacetyl Triazide:

This classic route involves the hydrolysis of acetoxyacetyl triazide, which is a known precursor of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate.
The hydrolysis step involves the treatment of acetoxyacetyl triazide with a strong acid, such as hydrochloric acid, to produce the desired compound.

2. Peyrone Salvamento Reaction:

The Peyrone Salvamento reaction is another classic route for the synthesis of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate.
In this route, a metal chloride is treated with a mixture of 3-chloro-4-hydroxy-5-nitrobenzaldehyde and triazole in the presence of a Lewis acid catalyst, such as aluminum chloride or ferric chloride, to produce the desired compound.

3. Perrine-Hormby Reaction:

The Perrine-Hormby reaction is another classic route for the synthesis of [3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate.
In this route, phthalic anhydride is treated with hydrazine and N,N-dimethylformamide to produce the desired compound.

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