The Synthetic Routes of 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI)

The chemical compound 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI) is an important intermediates in the production of various chemicals, pharmaceuticals, and other industrial products.
It is also known as 2,3-dimethyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-one.

Synthesis of 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI) can be achieved through a variety of synthetic routes.
One common method is via the reaction of 2-chloropyrimidine-5-carboxylic acid with 2-aminopyridine in the presence of a base such as sodium hydroxide.
This reaction leads to the formation of the intermediate 2-chloro-5-(2-amino-pyridin-3-yl)pyrimidine-4,6-dione, which can then be hydrolyzed to form 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI).

Another synthesis route for 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI) involves the reaction of 2-aminopyridine with 3-bromopyridine-5-carboxylic acid in the presence of an acid catalyst such as sulfuric acid.
This reaction leads to the formation of the intermediate 2-(3-bromopyridin-5-ylamino)pyridine-4,6-dione, which can then be reduced to form the desired product.

In addition to these synthesis routes, 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI) can also be synthesized via a variety of other methods, including the Robinson-Schöfheimer reaction, the Stille reaction, and the Suzuki reaction.
Each of these methods has its own advantages and disadvantages, and the choice of synthesis route will depend on the desired purity and yield of the product, as well as the availability and cost of the starting materials.

Overall, the synthesis of 2H-Pyrrolo[3,2-c]pyridin-2-one,1,3-dihydro-(9CI) is a complex process that requires careful selection of reagents and conditions.
However, once synthesized, this compound can be used as a key intermediate in the production of a wide range of chemicals and pharmaceuticals, making it an important chemical building block in the chemical industry.