The Synthetic Routes of 2(1H)-Quinolinone,6-amino-(9CI)

The Synthetic Routes of 2(1H)-Quinolinone,6-amino-(9CI)

2(1H)-Quinolinone,6-amino-(9CI) is a significant compound in the field of organic chemistry and has a wide range of applications in various industries.
The synthesis of 2(1H)-quinolinone,6-amino-(9CI) has been a topic of extensive research in the chemical industry due to its numerous applications.
This compound can be synthesized through different routes, and the selection of the route depends on the desired product and the available resources.
In this article, we will discuss the synthetic routes of 2(1H)-quinolinone,6-amino-(9CI) in the chemical industry.

Route 1: via 5-bromo-2-nitrobenzene

One of the most common routes for the synthesis of 2(1H)-quinolinone,6-amino-(9CI) involves the reaction of 5-bromo-2-nitrobenzene with sodium hydroxide in the presence of a solvent likeethylene glycol.
The reaction leads to the formation of 2,5-dibromo-1,4-benzoquinone, which can be further treated with ammonia to yield the desired product.

Route 2: via 2-amino-6-bromoquinoline

Another commonly used route involves the synthesis of 2-amino-6-bromoquinoline, which is then converted to 2(1H)-quinolinone,6-amino-(9CI).
This route involves the reaction of 2-bromo-6-nitroquinoline with ammonia to form 2-amino-6-bromoquinoline, which can then be hydrolyzed to yield the desired product.

Route 3: via 6-amino-2-(2,4-dinitrophenyl)quinoline

This route involves the synthesis of 6-amino-2-(2,4-dinitrophenyl)quinoline, which can then be reduced to yield 2(1H)-quinolinone,6-amino-(9CI).
The synthesis of 6-amino-2-(2,4-dinitrophenyl)quinoline involves the reaction of 2,4-dinitrophenylamine with 6-bromoquinoline in the presence of a solvent like acetic acid.

Route 4: via 6-aminomethyl-2(1H)-quinolinone

This route involves the synthesis of 6-aminomethyl-2(1H)-quinolinone, which can then be reduced to yield 2(1H)-quinolinone,6-amino-(9CI).
The synthesis of 6-aminomethyl-2(1H)-quinolinone involves the reaction of methylamine with 2(1H)-quinolinone in the presence of a solvent like sodium hydroxide.

Conclusion

The synthetic routes of 2(1H)-quinolinone,6-amino-(9CI) are diverse and can be selected based on the desired product and the available resources.
The above discussion highlights some of the most commonly used routes for the synthesis of this compound.
It is important to note that the selection of the route can have a significant impact on the cost and the environmental impact of the synthesis process.
Therefore, it is important to carefully consider the available resources and the desired product when selecting the synthetic route for this compound.