The Synthetic Routes of 2-(Trifluoromethyl)pyrimidine

2-(Trifluoromethyl)pyrimidine is a synthetic compound that is commonly used in the chemical industry.
It is an important building block in the synthesis of various pharmaceuticals, agrochemicals, and industrial chemicals.
The compound is synthesized through several methods, some of which will be discussed in this article.

Synthetic Route 1: via N-Fluorosulfonamide Intermediate

This route involves the conversion of a primary amine and a sulfur trioxide source in the presence of a fluoride source to yield the N-fluorosulfonamide intermediate.
The intermediate is then converted to 2-(trifluoromethyl)pyrimidine via a series of chemical reactions.

Synthetic Route 2: via N-Fluoroacetamide Intermediate

This route involves the conversion of a primary amine and a sulfur trioxide source in the presence of a fluoride source to yield the N-fluoroacetamide intermediate.
The intermediate is then converted to 2-(trifluoromethyl)pyrimidine via a series of chemical reactions.

Synthetic Route 3: via Halogenation of Pyrimidine-2-ol

This route involves the halogenation of pyrimidine-2-ol with a halogen source to yield 2-(trifluoromethyl)pyrimidine.

Synthetic Route 4: via Nitrile Halide Route

This route involves the reaction of a primary amine with nitromethane in the presence of a solvent to yield a nitrile.
The nitrile is then treated with a halogen source to yield 2-(trifluoromethyl)pyrimidine.

Synthetic Route 5: via Sulfenic Acid Intermediate

This route involves the conversion of a primary amine to the corresponding sulfenic acid intermediate.
The intermediate is then converted to 2-(trifluoromethyl)pyrimidine via a series of chemical reactions.

Synthetic Route 6: via Iodination of Pyrimidine-2-ol

This route involves the iodination of pyrimidine-2-ol with a iodine source to yield 2-(trifluoromethyl)pyrimidine.

Synthetic Route 7: via Borohydride Reduction of Nitro Compound

This route involves the reduction of a nitro compound with a borohydride reducing agent to yield 2-(trifluoromethyl)pyrimidine.

Synthetic Route 8: via Reduction of Nitroso Compound

This route involves the reduction of a nitroso compound with a reducing agent to yield 2-(trifluoromethyl)pyrimidine.

Synthetic Route 9: via Reduction of Nitrile with Lithium Aluminum Hydride

This route involves the reduction of a nitrile with lithium aluminum hydride to yield 2-(trifluoromethyl)pyrimidine.

In conclusion, there are several synthetic routes to 2-(trifluoromethyl)pyrimidine, which is an important building block in the synthesis of various pharmaceuticals, agrochemicals, and industrial chemicals.
The choice of the synthetic route depends on the availability of the starting materials and the specific requirements of the final product.