The Synthetic Routes of 2'-(trifluoroMethyl)-2,4'-bipyriMidine

Introduction

2'-(TrifluoroMethyl)-2,4'-bipyriMidine, also known as TFBM, is a novel synthetic molecule that has gained significant attention in recent years due to its unique properties and potential applications in various fields, including medicine, materials science, and organic electronics.
This synthetic molecule can be synthesized through different routes, and this article aims to provide an in-depth review of the synthetic routes of TFBM, including their advantages and disadvantages, as well as their potential applications in the chemical industry.

Synthetic Routes of TFBM

There are several synthetic routes for TFBM, including the classical route, the Ullmann reaction, and the Sharpless epoxidation method.
Each of these routes has its own advantages and disadvantages, depending on the desired product, reaction conditions, and the availability of starting materials.

Classical Route

The classical route for TFBM synthesis involves the condensation of 2,4-diamino-5-bromopyrimidine with 1-bromo-3-trifluoromethyl-5-pyridinemethanone in the presence of a solvent such as DMF or DMSO, followed by purification and deprotection.
This method involves several steps and requires the use of hazardous reagents, such as bromo compounds and trifluoroethanol.
Additionally, the purification and deprotection steps can be time-consuming and expensive.

Ullmann Reaction Route

An alternative route for TFBM synthesis involves the Ullmann reaction between 2,4-diamino-5-chloropyrimidine and 3-trifluoromethyl-5-pyridinemethanone in the presence of a base such as sodium hydroxide.
The reaction is typically carried out in a polar solvent such as water or dimethylformamide and requires lower temperatures and shorter reaction times compared to the classical route.
The Ullmann reaction method is simpler, more convenient, and more cost-effective than the classical route, as it involves fewer steps and the use of less hazardous reagents.

Sharpless Epoxidation Route

The Sharpless epoxidation method involves the conversion of 2,4-diamino-5-bromopyrimidine to 2'-(trifluoroMethyl)-2,4'-bipyriMidine through the Sharpless epoxidation reaction, followed by reduction with lithium aluminum hydride (LiAlH4).
This method is more efficient and selective than the classical route and involves fewer steps, as it eliminates the need for the deprotection step.
However, it requires the use of a strong reducing agent such as LiAlH4, which can be hazardous and costly.

Properties and Applications of TFBM

TFBM has a unique set of properties that make it an attractive molecule for various applications in the chemical industry.
These properties include its high thermal stability, high Hildebrandsolvation energy, hydrophobic nature, and unique electrochemical properties, which make it a suitable component in organic electronics, such as organic field-effect transistors (OFETs).

Organic Field-Effect Transistors (OFETs)

OFETs are electronic devices that use organic semiconductors to control the flow of electric current between two electrodes.
TFBM can be used as a building block for the design of new organic semiconductors with enhanced performance, as it has a high thermal stability and high Hildebrandsolvation energy, which leads to improved solubility and processability.
Additionally, TFBM has unique electrochemical properties, such as an unusual redox behavior and an independence of the redox behavior from the charge-transfer process, which can improve the performance