-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
The synthesis of 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) is a critical process in the chemical industry due to its wide range of applications.
This compound is used as an intermediate in the synthesis of various drugs and agrochemicals, and its unique properties make it an essential component in the production of these chemicals.
The synthesis of 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) can be accomplished through several synthetic routes.
The choice of synthetic route depends on the availability of starting materials, the desired yield, and the purity of the final product.
One of the most common synthetic routes for the synthesis of 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) is the Williamson ether synthesis.
In this process, 2-naphthol is treated with sodium hydroxide to form a sodium salt.
This salt is then treated with a Grignard reagent made from 1-ethyl-4-bromo-2,3-dimethylbenzene and lithium hydroxide.
The resulting product is then treated with hydrochloric acid to form the 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1).
Another synthetic route for the synthesis of 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) is the Speier synthesis.
In this process, 2-nitropropane is treated with a Grignard reagent made from 1-ethyl-4-bromo-2,3-dimethylbenzene and lithium hydroxide.
The resulting product is then treated with sodium hydroxide and hydrochloric acid to form the 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1).
A third synthetic route for the synthesis of 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) is the Wolff-Kishner reduction.
In this process, 2-chloro-1-ethyl-4-[2-(4-morpholinyl)ethyl]benzene is treated with potassium hydroxide and sodium hydroxide to reduce the chloride group.
The resulting product is then treated with sodium hydroxide and hydrochloric acid to form the 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1).
No matter which synthetic route is used, the synthesis of 2-pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) is a complex and multi-step process that requires careful control of reaction conditions to ensure the desired yield and purity of the final product.
