The Synthetic Routes of 2-Pyridinemethanamine,alpha-ethyl-(9CI)

2-Pyridinemethanamine, alpha-ethyl (9CI) is a derivative of the naturally occurring compound 2-pyridine methanamine.
It is commonly used in the chemical industry as a building block for the synthesis of various chemicals, drugs, and intermediates.
This article will discuss the various synthetic routes that are used to produce 2-Pyridinemethanamine, alpha-ethyl (9CI).

The most common synthetic route for 2-Pyridinemethanamine, alpha-ethyl (9CI) involves the reduction of 2-nitro-1,3-oxazolidine, which is then treated with a Grignard reagent to form the ethyl amide.
This reaction can be carried out using a variety of reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a noble metal catalyst.
The reaction can be depicted as follows:

2-nitro-1,3-oxazolidine + LiAlH4 → 2-Pyridinemethanamine, alpha-ethyl (9CI)

Another synthetic route for 2-Pyridinemethanamine, alpha-ethyl (9CI) involves the reduction of 2-chloro-1,3-oxazolidine, which is then treated with an ethyl halide and a Lewis acid catalyst to form the ethyl amide.
This reaction can be carried out using a variety of reducing agents such as hydrogen gas in the presence of a noble metal catalyst or lithium hydroxide.
The reaction can be depicted as follows:

2-chloro-1,3-oxazolidine + C2H5Cl → 2-Pyridinemethanamine, alpha-ethyl (9CI)

A third synthetic route for 2-Pyridinemethanamine, alpha-ethyl (9CI) involves the reduction of 2-nitro-1,3-oxazolidine using Schiff base condensation with ethyl acetate.
This reaction can be carried out by treating 2-nitro-1,3-oxazolidine with ethyl acetate in the presence of a dehydrating agent such as sodium hydroxide or concentrated sulfuric acid.
The reaction can be depicted as follows:

2-nitro-1,3-oxazolidine + C2H5C(O)OH → 2-Pyridinemethanamine, alpha-ethyl (9CI)

In conclusion, there are several synthetic routes for producing 2-Pyridinemethanamine, alpha-ethyl (9CI) in the chemical industry.
These routes involve reducing 2-nitro-1,3-oxazolidine or 2-chloro-1,3-oxazolidine using different reducing agents and reaction conditions.
The choice of synthetic route depends on various factors such as cost, availability of reagents, and the desired yield and purity of the final product.