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2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-2-[[(3-methyl-8-quinolinyl)sulfonyl]amino]-1-oxopentyl]-4-methyl-, (2R,4R)- or simply PIP210 is a synthetic compound that has been widely used in chemical industry due to its unique properties.
It is classified as a ligand and is commonly used as a pharmaceutical intermediate.
This compound has also been used in the production of various fine chemicals, agrochemicals, and other industrial chemicals.
PIP210 has a unique structure that is composed of a 2-piperidinecarboxylic acid backbone with a variety of functional groups attached to it.
The compound has a single chiral center and exists in two stereoisomers, (2R,4R) and (2S,4S).
The (2R,4R) stereoisomer is the more stable and predominant form of PIP210.
One of the most common synthetic routes for PIP210 is through a Widmer-Randall reaction.
This reaction involves the formation of a sulfonyl azide intermediate, which is then reduced to form the desired amide.
The reaction is highly stereospecific and allows for the formation of the (2R,4R) stereoisomer of PIP210.
Another common synthetic route for PIP210 is through a Ullmann reaction.
This reaction involves the formation of a tetrazole intermediate, which is then reduced to form the desired amide.
The reaction is also highly stereospecific and allows for the formation of the (2R,4R) stereoisomer of PIP210.
Both of these synthetic routes have been widely used in chemical industry due to their high efficiency and selectivity.
The Widmer-Randall reaction is particularly useful in the production of large quantities of PIP210, while the Ullmann reaction is useful for smaller scale syntheses.
In addition to these synthetic routes, PIP210 can also be synthesized through other methods such as hydrolysis of an amide or ester, or through a sequence of chemical reactions involving the formation of intermediate compounds.
Overall, PIP210 is an important synthetic compound in chemical industry due to its unique structure and stability.
Its stereoisomers have unique physical and chemical properties, and the compound is commonly used as a pharmaceutical intermediate and as a building block for the synthesis of other chemicals.
The Widmer-Randall and Ullmann reactions are two of the most common synthetic routes for PIP210, but other methods are also available for its synthesis.