The Synthetic Routes of 2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE

2-(Methylthio)-4-(tributylstanny)pyrimidine is an important organic compound that is widely used in the chemical industry.
This compound is often used as a building block for the synthesis of various chemicals, pharmaceuticals, and other products.
The synthetic routes for this compound can vary depending on the specific application and the desired product.
There are several different methods that can be used to synthesize 2-(methylthio)-4-(tributylstanny)pyrimidine, each with its own advantages and disadvantages.

One of the most common synthetic routes for this compound involves the reaction of 2-chloromethylthiophene with tributyl tin in the presence of a Lewis acid catalyst, such as aluminum chloride.
This reaction converts the 2-chloromethylthiophene into the desired 2-(methylthio)-4-(tributylstanny)pyrimidine.
This method is relatively simple and efficient, and can produce high yields of the desired product.
However, it requires the use of hazardous reactants and catalysts, and must be performed with caution to avoid potential health hazards.

Another synthetic route for 2-(methylthio)-4-(tributylstanny)pyrimidine involves the reaction of 2-methylthio-4-nitro-aniline with tributyl tin in the presence of a solvent, such as benzene or toluene.
This reaction converts the 2-methylthio-4-nitro-aniline into the desired 2-(methylthio)-4-(tributylstanny)pyrimidine.
This method is less hazardous than the first method, as it does not require the use of chlorinated compounds or Lewis acid catalysts.
However, it may be less efficient and could produce lower yields of the desired product.

In addition to the above synthetic routes, 2-(methylthio)-4-(tributylstanny)pyrimidine can also be synthesized using other methods, such as the reaction of 2-methylthio-5-(tributylstanny)furan with 2-chloro-4-nitro-aniline, or the reaction of 2-methylthio-4-nitro-aniline with tributyl tin in the presence of a reducing agent, such as hydrogen gas or sodium borohydride.
Each of these methods has its own advantages and disadvantages, and the choice of synthetic route will depend on the specific application and the desired product.

Once synthesized, 2-(methylthio)-4-(tributylstanny)pyrimidine can be used as a building block for the synthesis of various chemicals and pharmaceuticals.
For example, it can be used in the synthesis of antiviral drugs, such as ribavirin, or in the synthesis of anti-inflammatory agents, such as celecoxib.
It can also be used in the synthesis of polymers, such as polyimides, or in the production of other organic compounds.
The versatility of 2-(methylthio)-4-(tributylstanny)pyrimidine makes it a valuable building block in the chemical industry, and its synthetic routes are an important area of research and development.