The Synthetic Routes of 2-Methylquinazoline

2-Methylquinazoline is an important organic compound that finds widespread applications in various industries, including pharmaceuticals, agrochemicals, and chemical synthesis.
It is a colorless liquid with a characteristic amine odor and is used as a building block for the synthesis of various other chemicals.
The synthetic routes to 2-methylquinazoline can be classified into several categories based on the starting materials and the reaction conditions used.

One of the most common synthetic routes to 2-methylquinazoline involves the reaction of aniline with formaldehyde in the presence of an acid catalyst.
The reaction proceeds through the intermediate formation of o-toluidine, which is then hydrogenated to form 2-methylquinazoline.
This route is simple, inexpensive, and offers good yield, making it a popular choice in industry.

Another synthetic route to 2-methylquinazoline involves the reaction of methyl iodide with sodium hydrosulfite to form the corresponding methyl sulfate intermediate, which is then reduced with hydrogen in the presence of a catalyst, such as palladium on barium oxide, to form 2-methylquinazoline.

A third synthetic route to 2-methylquinazoline involves the reaction of dimethyl sulfate with sodium hydroxide to form the corresponding sodium salt, which is then treated with dimethylamine to form the corresponding dimethylamine salt.
The salt is then hydrolyzed using hydrochloric acid to form 2-methylquinazoline.

In addition to the above-mentioned synthetic routes, there are several other methods that have been reported in the literature for the synthesis of 2-methylquinazoline.
These include the use of reducing agents such as lithium aluminum hydride, the reaction of methyl iodide with sodium nitrite, and the reaction of methyl iodide with sodium sulfite.

The choice of synthetic route to 2-methylquinazoline depends on several factors, including the desired yield, the cost and availability of reaction materials, and the purity of the desired