The Synthetic Routes of 2-methyl-3(2H)-Pyridazinone

2-methyl-3(2H)-pyridazinone is a key chemical in the pharmaceutical and agrochemical industries.
It is used as an intermediate in the synthesis of a number of important compounds, such as antibiotics, fungicides, and herbicides.
The synthesis of 2-methyl-3(2H)-pyridazinone can be achieved through several different routes, including synthetic, hydrolytic, and electrochemical methods.

One of the most commonly used synthetic routes for the synthesis of 2-methyl-3(2H)-pyridazinone involves the reaction of 2-methyl-1,3-oxazolidine-3-one with hydrazine.
This reaction occurs in the presence of a base, such as sodium hydroxide, and results in the formation of 2-methyl-3(2H)-pyrazolone.
The latter compound is then reduced to 2-methyl-3(2H)-pyridazinone using a reducing agent, such as hydrogen in the presence of a metal catalyst, like palladium on barium sulfate.

Another synthetic route for the synthesis of 2-methyl-3(2H)-pyridazinone involves the reaction of 2-methyl-1,3-oxazolidine-3-one with sodium nitrite in the presence of a solvent, such as dimethylformamide.
This reaction results in the formation of 2-methyl-3(2H)-pyrazoline, which can be further converted to 2-methyl-3(2H)-pyridazinone using a reducing agent, such as sodium borohydride.

Hydrolytic routes for the synthesis of 2-methyl-3(2H)-pyridazinone involve the reaction of 2-methyl-3-oxazolidinone with a strong acid, such as sulfuric acid.
This reaction results in the cleavage of the oxazolidine ring and the formation of 2-methyl-3-pyrazole.
The latter compound can then be converted to 2-methyl-3(2H)-pyridazinone using a reducing agent, such as hydrogen in the presence of a metal catalyst, like palladium on barium sulfate.

Electrochemical routes for the synthesis of 2-methyl-3(2H)-pyridazinone involve the use of electrolysis to drive the reduction of 2-methyl-3-oxazolidinone to 2-methyl-3-pyrazole.
The latter compound can then be converted to 2-methyl-3(2H)-pyridazinone using a reducing agent, such as hydrogen in the presence of a metal catalyst, like palladium on barium sulfate.

The synthetic routes of 2-methyl-3(2H)-pyridazinone can vary depending on the starting materials and the desired product.
The use of reducing agents, solvents, and metal catalysts can affect the yield and selectivity of the reaction, and the choice of synthetic route will depend on the specific application of the compound.

In conclusion, 2-methyl-3(2H)-pyridazinone is an important intermediate in the pharmaceutical and agrochemical industries, and several synthetic routes have been developed for its synthesis.
The most commonly used synthetic routes involve the reaction of 2-methyl-1,3-oxazolidine-3-one with hydrazine or sodium nitrite in the presence of a solvent and a metal catalyst.
Other synthetic routes involve the use of strong acids or electrolysis to drive the reduction of 2-methyl-3