The Synthetic Routes of 2-CYANOACETAMIDE, [CYANO-14C]

2-Cyanacetamide, also known as [Cyan-14C] 2-cyanacetamide, is a commonly used synthetic intermediate in the chemical industry.
It is used in a variety of applications, including the production of pharmaceuticals, agrochemicals, and other industrial chemicals.

Synthetic Route 1: Hydrolysis of N-Cyanomethyl-2-nitropropionamide
The first synthetic route for 2-cyanacetamide involves the hydrolysis of N-cyanomethyl-2-nitropropionamide.
This reaction involves the treatment of N-cyanomethyl-2-nitropropionamide with water under basic conditions.
The hydrolysis reaction results in the formation of 2-cyanacetamide and 2-nitropropionic acid.

Synthetic Route 2: Reduction of N-Cyanomethyl-2-nitrobenzamide
Another synthetic route for 2-cyanacetamide involves the reduction of N-cyanomethyl-2-nitrobenzamide.
This reaction involves the treatment of N-cyanomethyl-2-nitrobenzamide with a reducing agent such as hydrogen gas in the presence of a catalyst such as platinum oxide.
The reduction reaction results in the formation of 2-cyanacetamide and N-cyanomethyl-2-nitrobenzaldehyde.

Synthetic Route 3: From Cyanogen Chloride and Acetamide
2-cyanacetamide can also be synthesized by reacting cyanogen chloride with acetamide.
This reaction involves the formation of a cyanate ester, which can then be hydrolyzed to produce 2-cyanacetamide.
This route is less commonly used due to the potential hazards associated with the use of cyanide compounds.

Synthetic Route 4: From N-Cyanobenzylidene Amine and Acetyl Chloride
Another synthetic route for 2-cyanacetamide involves the reaction of N-cyanobenzylidene amine with acetyl chloride.
This reaction results in the formation of the cyanate ester, which can then be hydrolyzed to produce 2-cyanacetamide.

Applications of 2-Cyanacetamide
2-cyanacetamide is widely used in the production of pharmaceuticals, agrochemicals, and other industrial chemicals.
It is a versatile intermediate that can be converted into a variety of different compounds through a number of different chemical reactions.

One of the most common applications of 2-cyanacetamide is in the production of pharmaceuticals.
It is used as an intermediate in the synthesis of a number of different types of drugs, including anti-depressants, anti-inflammatory drugs, and opioid analgesics.

2-cyanacetamide is also used in the production of agrochemicals, such as herbicides and pesticides.
It is used as a starting material in the synthesis of these compounds due to its ability to undergo a variety of chemical reactions.

Other applications of 2-cyanacetamide include its use in the production of dyes, plastics, and other industrial chemicals.
It is a versatile intermediate that can be converted into a wide range of different products through a variety of chemical reactions.

2-cyanacetamide is a widely used synthetic intermediate in the chemical industry due to its ability to undergo a variety of chemical reactions.
It is used in the production of pharmaceuticals, agrochemicals, and other industrial chemicals, and its versatility and ease of synthesis make it an attractive building block for a variety of chemical syntheses.