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2-Chloroquinolin-6-amine, also known as quinine amine or chloroquine amine, is a synthetic compound that has been widely used in the pharmaceutical and chemical industries.
Its synthetic routes have been studied extensively over the years, with various methods developed to synthesize this compound efficiently and cost-effectively.
One of the most common synthetic routes for 2-chloroquinolin-6-amine involves the reaction of chlorine with quinoline-6-carbaldehyde to form the corresponding N-chloramine, which is then reduced to the amine using hydrogenation.
This route involves several steps, including the preparation of the starting materials, the reaction steps, and the purification and isolation of the final product.
Another synthetic route for 2-chloroquinolin-6-amine involves the reaction of chlorine with quinoline-6-sulfonic acid to form the corresponding N-chloroamide, which is then hydrolyzed to the amine using acidification.
This route is also multi-step process that involves the preparation of the starting materials, the reaction steps, and the purification and isolation of the final product.
In recent years, efforts have been made to develop more efficient and cost-effective synthetic routes for 2-chloroquinolin-6-amine.
One such method involves the use of microwave irradiation to accelerate the reaction, which has been shown to significantly reduce the reaction time and increase the yield.
Another approach involves the use of green chemistry principles, such as the use of water as a solvent and the elimination of toxic reagents, to create a more environmentally friendly synthesis route.
In addition to these synthetic routes, there have also been efforts to develop alternative methods for the production of 2-chloroquinolin-6-amine.
These include the use of biotechnological methods, such as the expression of the enzyme responsible for its synthesis in bacteria or yeast, and the use of hydrolysis of organic compounds to produce the amine.
Overall, the synthetic routes for 2-chloroquinolin-6-amine have undergone significant evolution over the years, with new methods being developed to improve efficiency, reduce cost, and minimize environmental impact.
As the demand for this compound continues to grow, it is likely that new methods for its synthesis will be developed to meet the needs of the pharmaceutical and chemical industries.