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The synthesis of (2-chloro-pyrimidin-4-ylmethyl)-isopropyl-amine, commonly referred to as CPI-0610, is a complex process that involves multiple synthetic routes.
The synthesis of this compound is of great interest in the chemical industry due to its potential use as an antiviral drug.
One of the most common synthetic routes for CPI-0610 involves a sequence of reactions that starts with the creation of a substituted aniline.
This is followed by a condensation reaction with an aromatic aldehyde, which is then reduced to an alcohol.
The alcohol is then reacted with (4-chloro-2-oxo-pyrimidin-1-yl)acetaldehyde, which is converted to the desired amine through a series of hydrolysis, condensation, and reduction reactions.
Another synthetic route for CPI-0610 involves the use of a Grignard reagent.
This process starts with the creation of a Grignard reagent from a substituted benzaldehyde.
The Grignard reagent is then reacted with (4-chloro-2-oxo-pyrimidin-1-yl)acetaldehyde to form an intermediate, which is then reduced to the desired amine.
Yet another synthetic route for CPI-0610 involves the use of anoxime synthesis.
This process starts with the creation of a substituted aniline, which is then treated with hydrazine to form a diazonium salt.
The diazonium salt is then treated with an aromatic aldehyde and sodium hydroxide to form a quinoneimine.
The quinoneimine is then reduced to the desired amine using hydrogenation.
Each of these synthetic routes has its own advantages and disadvantages, and the choice of route depends on a variety of factors, such as cost, availability of reagents, and the desired yield.
In conclusion, the synthesis of CPI-0610 is a complex process that involves multiple synthetic routes.
These routes include the use of a substituted aniline, Grignard reagents, and anoxime synthesis.
The choice of route depends on a variety of factors, and the desired yield is the most important consideration.
The synthesis of CPI-0610 is of great interest in the chemical industry due to its potential use as an antiviral drug.
