The Synthetic Routes of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide

2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals.
It is also used as a research chemical in chemical and pharmaceutical laboratories.
The synthetic routes of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide can be broadly classified into two categories: organic and inorganic methods.

Organic Synthetic Routes:
The most commonly used organic method for the synthesis of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide is the reaction of 4-chloro-2-fluoropyridine with N-ethylaniline in the presence of a base such as sodium hydroxide.
The reaction results in the formation of 4-chloro-2-ethylpyridine, which is then converted into 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide by treating it with carbon tetrachloride and hydrogen chloride in the presence of a catalyst such as zinc chloride.

Another organic synthetic route for the synthesis of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide involves the reaction of N-ethylaniline with 2-chloropropionyl chloride in the presence of a solvent such as dichloromethane.
The reaction is followed by the addition of pyridine and sodium hydroxide to the reaction mixture, resulting in the formation of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide.

Inorganic Synthetic Routes:
The inorganic synthetic route for the synthesis of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide involves the reaction of 2-chloro-4-nitrophenyl sulfate with N-ethyl-N-(2-chloro-4-nitrophenyl)amine in the presence of a solvent such as methanol.
The reaction is followed by the addition of sodium hydroxide and sodium bicarbonate, resulting in the formation of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide.

Advantages and Limitations of Synthetic Routes:
The organic synthetic routes of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide are relatively less expensive and involve the use of easily available starting materials.
These routes are also highly scalable and can be easily adapted for commercial production.
However, these methods can be time-consuming and may require the use of hazardous reagents.

The inorganic synthetic route for 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide is more environmentally friendly and does not require the use of hazardous reagents.
However, this method is more expensive and may require the use of specialized equipment.

Conclusion:
In conclusion, the synthetic routes of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide vary depending on the starting materials and the method chosen.
While the organic routes are relatively less expensive and highly scalable, the inorganic route is more environmentally friendly and does not require the use of hazardous reagents.
The selection of a particular synthetic route depends on the specific needs and requirements of the production process.