The Synthetic Routes of 2-chloro-N-cyclopropyl-6-methylpyrimidin-4-amine

The synthesis of 2-chloro-N-cyclopropyl-6-methylpyrimidin-4-amine is an important process in the chemical industry due to its wide range of applications.
In this article, we will explore the synthetic routes for this compound.

1. Direct Synthesis Route
   The direct synthesis route involves the reaction of cyclopropyl amine with chloroacetamide, followed by reduction of the resulting N-chloroamide with lithium aluminum hydride (LiAlH4) to form the final product.
   This route is relatively straightforward, but it requires careful handling of the reagents to avoid unwanted side reactions.
   
2. Indirect Synthesis Route
   The indirect synthesis route involves the reaction of 2-chloro-6-methylpyrimidine-5-carbaldehyde with cyclopropyl amine to form the N-cyclopropylated derivative, which is then reduced with LiAlH4 to form the final product.
   This route is more complex than the direct synthesis route, but it provides better control over the reaction conditions and reduces the risk of unwanted side reactions.
   
3. Mannich Bock Reaction Route
   The Mannich-Bock reaction is another route for the synthesis of 2-chloro-N-cyclopropyl-6-methylpyrimidin-4-amine.
   In this route, an imine is formed between cyclopropyl amine and formaldehyde, followed by reaction with chloroacetaldehyde to form the N-chloro derivative.
   The resulting N-chloro compound is then reduced with LiAlH4 to form the final product.
   

Overall, the synthetic routes for 2-chloro-N-cyclopropyl-6-methylpyrimidin-4-amine vary in complexity, but each route provides a reliable method for the synthesis of this compound.
The choice of route depends on the specific requirements of the application and the expertise of the synthetic chemist.
The direct and indirect synthesis routes are more commonly used in industry due to their simplicity and scalability, while the Mannich-Bock route is more commonly used in research settings due to its sensitivity and selectivity.