The Synthetic Routes of 2-aMino-6-(broMoMethyl)pyriMidin-4-ol

2-Amino-6-(broMoMethyl)pyriMidin-4-ol, also known as BCM-417, is a synthetic compound that has gained significant attention in the chemical industry due to its unique properties and broad range of applications.
The synthetic route for BCM-417 can be divided into several steps, each with its own set of challenges and considerations.

The first step in the synthesis of BCM-417 is the preparation of the intermediate compound 2-(2,4-difluorotoluoyl)amino-6-(methylamino)pyridine-3-carbonitrile.
This compound is synthesized by a multi-step reaction sequence that involves the condensation of 2,4-difluorotoluene with 2-aminopyridine, followed by the introduction of a methyl group through a Suzuki reaction.

The next step is the reduction of the nitro group in the intermediate compound to form the corresponding amino group.
This is typically done using a reducing agent such as lithium aluminum hydride (LiAlH4) in the presence of a solvent such as ether.

Next, the synthesis of BCM-417 involves the addition of a boronic acid moiety to the reduced intermediate compound.
The boronic acid is typically provided as a boronic acid ester, which is first converted to the corresponding boronic acid hydride before being added to the reduced intermediate compound in the presence of a catalyst such as cobalt(III) chloride.

Finally, the synthesis of BCM-417 is completed through the addition of a methyl group to the boronic acid moiety.
This is typically done using a transfer hydrogenation reaction, in which a metal hydride such as lithium aluminum hydride (LiAlH4) is used to transfer hydrogen to the boronic acid moiety, resulting in the formation of the final product.

Overall, the synthesis of BCM-417 involves a series of multi-step reactions that require careful selection of reagents and reaction conditions to ensure high yield and purity of the final product.
The synthesis of BCM-417 is a challenging synthetic task, but its unique properties and applications make it a valuable compound in the chemical industry.