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The synthesis of 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-, sulfate, also known as Vitamin B12, is an important process in the chemical industry.
Vitamin B12 is a essential nutrient for humans and animals, and it is widely used in the production of food supplements, pharmaceuticals, and cosmeceuticals.
There are various synthetic routes for the production of Vitamin B12, and the choice of route depends on factors such as the scale of production, the purity of the desired product, and the cost of the starting materials.
The most commonly used synthetic routes for Vitamin B12 are outlined below.
- Reduction of 4-Amino-5-bromo-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-3-one
This is the most common synthetic route for the production of Vitamin B12.
The starting material for this route is 4-Amino-5-bromo-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-3-one, which is derived from tryptophan.
This compound is reduced using hydrogen in the presence of a catalyst, such as palladium on barium sulfate, to form Vitamin B12.
- Reduction of 4-Amino-5-chloro-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-3-one
This route is similar to the first route, but the starting material is 4-Amino-5-chloro-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-3-one, which is also derived from tryptophan.
This compound is reduced using hydrogen in the presence of a catalyst to form Vitamin B12.
- Reduction of 4-Amino-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-5-one
This route involves the reduction of 4-Amino-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-5-one, which is derived from tryptophan, using hydrogen in the presence of a catalyst to form Vitamin B12.
- Reduction of 4-Amino-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-6-one
This route involves the reduction of 4-Amino-2,3-dihydroimidazo[1,2-d][1,4]benzoxazepin-6-one, which is derived from tryptophan, using hydrogen in the presence of a catalyst to form Vitamin B12.
In conclusion, the synthetic routes of Vitamin B12 involve the reduction of various starting materials derived from tryptophan.
These routes are commonly used in the chemical industry for the production of Vitamin B12, and the choice of route depends on factors such as the scale of production, the purity of the desired product, and the cost of the starting materials.
Vitamin B12 is an essential nutrient for humans and animals, and it is widely used in the production of food supplements, pharmaceuticals, and cosmeceuticals.
