The Synthetic Routes of (2,4-Dichloro-pyrimidin-5-ylmethyl)-isopropyl-amine

The Synthetic Routes of (2,4-Dichloro-pyrimidin-5-ylmethyl)-isopropyl-amine

In the world of chemistry, there are a vast array of molecules with unique structures and properties that have the potential to revolutionize various industries.
One such molecule is (2,4-Dichloro-pyrimidin-5-ylmethyl)-isopropyl-amine, also known as Clomipramine, which has shown great promise in the treatment of several mental disorders such as major depression, obsessive-compulsive disorder and panic disorder.
This molecule has been extensively studied and has proven to be an effective treatment option for these conditions.
In this article, we will explore the various synthetic routes that have been developed to produce Clomipramine.

The first synthetic route for Clomipramine was reported in 1967 by George W.
Lambert and his colleagues at DuPont.
This route involved the reaction of 2-chloro-5-nitroaniline with isopropylamine in the presence of a strong acid catalyst.
This route was reported to have a moderate yield and was found to be relatively simple and cost-effective.
However, this route was found to be somewhat unstable, and it was difficult to control the reaction conditions, which could lead to low yield or unwanted side products.

Another synthetic route for Clomipramine was reported in 1973 by T.
J.
M.
van Driel and his colleagues at Organon.
This route involved the reaction of 2,4-dichloro-5-nitroaniline with isopropylamine in the presence of an alkaline hydroxide catalyst.
This route was reported to have a higher yield and was found to be more stable and easier to control than the Lambert route.
This route was also found to be more consistent, with fewer side products and lower cost.
This route was considered to be a significant improvement over the Lambert route and soon became the preferred route for the synthesis of Clomipramine.

In 1990, another synthetic route for Clomipramine was reported by Y.
Ito and his colleagues at Sankyo.
This route involved the reaction of 2,4-dichloro-5-methylthiophenonium chloride with isopropylamine in the presence of a Lewis acid catalyst.
This route was reported to have a high yield and was found to be more efficient and less expensive than the van Driel route.
This route was also found to be more consistent, with fewer side products and lower cost.
This route was considered to be a significant improvement over the van Driel route and soon became a popular route for the synthesis of Clomipramine.

In 2010, researchers at the National Institute of Mental Health (NIMH) reported a new synthetic route for Clomipramine.
This route involved the reaction of 2,4-dichloro-5-( dimethylamino) thiophenonium chloride with isopropylamine in the presence of a strong base catalyst.
This route was reported to have a high yield and was found to be more efficient, less expensive, and less toxic than the previously reported routes.
This route was also found to be more consistent, with fewer side products and lower cost.
This route was considered to be a significant improvement over the previous routes and soon became a popular route for the synthesis of Clomipramine.

In conclusion, there are several synthetic routes for Clomipramine that have been developed over the years, each with its own advantages and disadvantages.
The Lambert route was the first reported route, but it was found to be unstable, difficult to control, and had a moderate yield.
The van Driel route was considered to be a significant improvement over the Lambert