The Synthetic Routes of 2,4-Diamino-6-hydroxypyrimidine

The Synthetic Routes of 2,4-Diamino-6-Hydroxypyrimidine: A Comprehensive Overview in the Chemical Industry

2,4-Diamino-6-hydroxypyrimidine, also known as DAPY, is an important building block in the field of organic synthesis.
This molecule has a wide range of applications in the chemical industry, including the synthesis of dyes, pigments, and agrochemicals.
The synthetic routes for DAPY have been extensively studied, and several methods have been developed over the years.
In this article, we will provide a comprehensive overview of the synthetic routes for 2,4-diamino-6-hydroxypyrimidine.

I.
via 3-Amino-2-hydroxypyrimidine (AHP)

One of the most commonly used synthesis routes for 2,4-diamino-6-hydroxypyrimidine is through the intermediate 3-amino-2-hydroxypyrimidine (AHP).
This route involves several steps, including the synthesis of AHP from urea and formaldehyde, followed by oxidation of AHP to DAP.
The final step involves reduction of the nitrogen atom to form DAPY.
This route is relatively simple and widely used in industry.

II.
Via 2,4-Diaminopyrimidine (DAP)

Another commonly used synthetic route for DAPY is through the intermediate 2,4-diaminopyrimidine (DAP).
This route involves the synthesis of DAP from ammonia and hydrochloric acid, followed by oxidation of DAP to DAPO.
The final step involves reduction of DAPO to form DAPY.
This route is also widely used in industry and is simpler than the first route.

III.
Via 2,4-Dihydroxypyrimidine (DHP)

A relatively recent synthetic route for DAPY is through the intermediate 2,4-dihydroxypyrimidine (DHP).
This route involves the synthesis of DHP from glucose and chloroform, followed by nitration of DHP to form DAPON.
The final step involves reduction of DAPON to form DAPY.
This route is more complex than the first two routes, but it is environmentally friendly and has the advantage of being a one-pot process.

IV.
Via 2,6-Diamino-5-hydroxypyrimidine (DAHP)

An alternative synthetic route for DAPY is through the intermediate 2,6-diamino-5-hydroxypyrimidine (DAHP).
This route involves the synthesis of DAHP from uronic acid and formaldehyde, followed by reduction of DAHP to form DAPH.
The final step involves oxidation of DAPH to form DAPY.
This route is relatively complex, but it has the advantage of avoiding the use of chlorinated compounds.

V.
via 3-Hydroxy-2-naphthaldehyde

Another synthetic route for DAPY involves the synthesis of 3-hydroxy-2-naphthaldehyde, followed by reduction to form 2,4-diamino-6-hydroxypyrimidine.
This route is relatively less commonly used in industry, but it has the advantage of being a one-pot process.

VI.
via 2,4-Diaminocyclohexane-1,2-dione

2,4-diaminocyclohexane-1,2-dione is another intermediate used in the synthesis of DAPY.
This intermediate is synthesized from cyclohexanone and am