-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
2,4-Diaminopyrimidine (DAP) is an important organic compound that has a wide range of applications in the chemical industry.
The compound is used as a building block in the synthesis of various chemicals and pharmaceuticals.
One of the most important synthetic routes of 2,4-DAP is the synthesis of the compound via the oxidation of 2,4-diaminopyrimidine-5-one (DAPO).
In this route, DAPO is first treated with sodium hydroxide and then with hydrogen peroxide to yield 2,4-DAP.
Another synthetic route for 2,4-DAP is the synthesis of the compound via the reduction of 2,4-diaminopyrimidine 5-oxide (DAPO).
In this route, DAPO is treated with a reducing agent such as hydrogen in the presence of a catalyst to yield 2,4-DAP.
Another route is the synthesis of 2,4-DAP via the reaction of pyrimidine-5-carboxaldehyde with an excess of ammonia in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.
Yet another route is the reaction of 2-amino-4-chloropyrimidine with a primary amine in the presence of a condensing agent, such as dicyclohexylcarbodiimide (DCC) or hydrochloric acid.
2,4-Diaminopyrimidine is also synthesized via the reaction of pyrimidine-5-carbaldehyde with excess ethyl amine in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.
2,4-Diaminopyrimidine can also be synthesized via the reaction of (2,4-diaminopyrimidine-5-ylidene)acetaldehyde with an excess of ammonia in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.
In the above mentioned synthetic routes, the choice of the reaction conditions, the reagents, and the catalyst plays an important role in the yield and the purity of the product.
In conclusion, 2,4-Diaminopyrimidine is a versatile compound with a wide range of applications in the chemical industry.
The compound can be synthesized via several synthetic routes, each with its own advantages and disadvantages.
The choice of the synthetic route depends on the specific requirements of the application and the desired properties of the final product.
