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    Home > Medical News > Medical Research Articles > The Synthetic Routes of 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

    The Synthetic Routes of 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

    • Last Update: 2023-05-14
    • Source: Internet
    • Author: User
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    The synthesis of 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one is a challenging synthetic route that requires the use of various chemical reactions and techniques.
    The following article will provide a detailed account of the synthetic routes of this compound in the chemical industry, including the various methods and techniques used to synthesize it.


    One of the most common synthetic routes for 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one is through the Robinson-Williams epoxidation reaction.
    This reaction involves the use of hydrogen peroxide and sodium hydroxide to convert alkenes into epoxides.
    By using this method, 3,4-dimethylbenzaldehyde, a precursor to the target compound, can be converted into the desired product.


    Another common synthetic route for 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one is through the use of the Peterson olefination reaction.
    This reaction involves the use of a palladium catalyst and sodium carbonate to convert an aldehyde into an alkene.
    By using this method, 3,4-dimethylbenzaldehyde can be converted into the desired alkene precursor, which can then be subjected to the Peterson reaction to form the desired product.


    In addition to the Robinson-Williams epoxidation reaction and the Peterson olefination reaction, there are several other synthetic routes for 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one.
    These include the use of Pd/C catalyst in the presence of an hydroxyl donor such as sodium hydroxide or quinoline, the use of osmium tetroxide/ dichlorobis(triphenylphosphine)oxaziridine in the presence of sodium hydroxide, and the use of manganese dioxide/dibutyl sebacate to form the desired product.


    The synthesis of 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one is a complex process that requires the use of various chemical reactions and techniques.
    The Robinson-Williams epoxidation reaction and the Peterson olefination reaction are two of the most common synthetic routes for this compound, but there are several other methods that can be used as well.
    The selection of a specific synthetic route will depend on the availability of reagents and the desired yield of the product.


    In conclusion, 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one is a challenging synthetic compound that requires the use of various chemical reactions and techniques.
    The Robinson-Williams epoxidation reaction and the Peterson olefination reaction are two common synthetic routes for this compound, but there are several other methods that can be used as well.
    The selection of a specific synthetic route will depend on the availability of reagents and the desired yield of the product.
    The synthesis of this compound is an important step in the chemical industry and will continue to be a subject of research and development in the future.


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