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    Home > Active Ingredient News > Antitumor Therapy > The Synthetic Routes of 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate

    The Synthetic Routes of 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate

    • Last Update: 2023-05-11
    • Source: Internet
    • Author: User
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    2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate is an important intermediate in the synthesis of various chemicals and pharmaceuticals.
    It is used as a building block for the synthesis of antiviral drugs, anti-inflammatory agents, and antibacterial agents.
    The synthesis of 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate involves several steps, and the choice of the synthesis route depends on the availability of the starting materials and the desired product.


    One of the most common synthetic routes for 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate involves the use of a method called the "Williams-Boyland reaction.
    " This reaction involves the treatment of 2-chloromethyl-6-oxo-1,2,4-triazepine with sodium acetate in the presence of a solvent such as dichloromethane or chloroform.
    The reaction produces the desired product, which can then be purified by chromatography or crystallization.


    Another synthetic route for 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate involves the use of a method called the "Jennings-Brown reaction.
    " This reaction involves the treatment of a substituted phenol with a substituted aldehyde in the presence of a base such as sodium hydroxide and a solvent such as ethanol.
    The reaction produces the desired product, which can then be purified by chromatography or crystallization.


    A third synthetic route for 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate involves the use of a method called the "Michael addition.
    " This reaction involves the treatment of 2-bromomethyl-6-oxo-1,2,4-triazepine with an aldehyde in the presence of a catalyst such as sodium hydroxide and a solvent such as dimethylformamide.
    The reaction produces the desired product, which can then be purified by chromatography or crystallization.


    In addition to these synthetic routes, there are several other methods that have been developed for the synthesis of 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate.
    These methods include the use of Grignard reagents, the treatment of a substituted phenyl chloride with a substituted amine, and the use of a Rh complex.


    The choice of the synthetic route for 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate depends on the availability of the starting materials and the desired product.
    The synthetic routes described above are just a few examples of the many methods that have been developed for the synthesis of this compound.
    The synthesis of 2-((2-Acetamido-6-oxo-1H-purin-7(6H)-yl)methoxy)ethyl acetate is an important step in the synthesis of many chemicals and pharmaceuticals, and the development of new and efficient synthetic routes for this compound is an active area of research in the chemical industry.



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