The Synthetic Routes of 2-[(2,6-Dichlorobenzyl)oxy]ethanol

2-[(2,6-Dichlorobenzyl)oxy]ethanol, also known as 2,6-dichloroethoxyethanol, is a synthetic chemical compound commonly used in the chemical industry.
It is a colorless liquid with a characteristic odor, and it is soluble in water and many organic solvents.
2-[(2,6-Dichlorobenzyl)oxy]ethanol is used as a building block in the synthesis of various chemicals, including surfactants, emulsifiers, and fragrances.

There are several synthetic routes to 2-[(2,6-dichlorobenzyl)oxy]ethanol, each with its own advantages and disadvantages.
The following are some of the most common synthetic routes:

1. The Hydrolysis of 2,6-Dichloro-N-[2-(hydroxymethyl)phenyl]acetamide

One of the most commonly used synthetic routes to 2-[(2,6-dichlorobenzyl)oxy]ethanol involves the hydrolysis of 2,6-dichloro-N-[2-(hydroxymethyl)phenyl]acetamide, which is a precursor compound.
The hydrolysis reaction involves the use of water to cleave the amide bond in the precursor compound, leading to the formation of 2-[(2,6-dichlorobenzyl)oxy]ethanol and the corresponding amine.
This route is relatively simple and straightforward, and the precursor compound is easily available, making it a popular choice in the chemical industry.

2. The Grignard Reaction of 2,6-Dichlorobenzaldehyde

Another popular synthetic route to 2-[(2,6-dichlorobenzyl)oxy]ethanol involves the use of the Grignard reaction, which is a common organic synthesis reaction.
The reaction involves the treatment of 2,6-dichlorobenzaldehyde with magnesium metal to form a Grignard reagent.
The Grignard reagent is then treated with water and an acid catalyst to initiate the hydrolysis reaction, leading to the formation of 2-[(2,6-dichlorobenzyl)oxy]ethanol.
This route is also relatively simple and straightforward, and it allows for the convenient synthesis of 2-[(2,6-dichlorobenzyl)oxy]ethanol from readily available starting materials.

3. The Reduction of 2-Chloro-6-(dimethylamino)benzaldehyde

2-Chloro-6-(dimethylamino)benzaldehyde is another precursor compound that can be used to synthesize 2-[(2,6-dichlorobenzyl)oxy]ethanol.
The reduction of 2-chloro-6-(dimethylamino)benzaldehyde involves the use of a reducing agent, such as lithium aluminum hydride, to reduce the aldehyde group to a methylene group, leading to the formation of 2-[(2,6-dichlorobenzyl)oxy]ethanol.
This route is also relatively simple and straightforward, and it allows for the synthesis of 2-[(2,6-dichlorobenzyl)oxy]ethanol from a readily available starting material.

4. The Reductive Amination of 2,6-Dichloro-N-(2-hydroxyethyl)acetamide

2,6-Dichloro-N-(2-hydroxyethyl)acetamide is another precursor compound that can be used to synthesize 2-[(2,