The Synthetic Routes of 1-Cinnamylpiperazine

1-Cinnamylpiperazine is a versatile organic compound that is widely used in the chemical industry.
Its synthetic routes have evolved over the years due to advances in synthetic organic chemistry.
This article will explore the different synthetic routes that have been developed to synthesize 1-cinnamylpiperazine.

Early Synthetic Routes

The first synthetic route for 1-cinnamylpiperazine was reported in 1905 by Emil Fischer, a German chemist.
He synthesized the compound by reacting cinnamaldehyde with ammonia in the presence of a strong acid catalyst.
This route involved several steps and was quite complex.

Later, in 1923, another synthetic route was reported by Hans von Pechmann, a German chemist.
He synthesized 1-cinnamylpiperazine by reacting iodoacetamide with cinnamaldehyde in the presence of a base catalyst.
This route was more efficient than Fischer's route, but it still involved several steps.

Improved Synthetic Routes

In the 1950s and 1960s, new synthetic routes for 1-cinnamylpiperazine were developed that were more efficient and less complex than the earlier routes.
One such route was reported by H.
J.
Busscher and M.
P.
de Vroom in 1958.
They synthesized the compound by reacting cinnamaldehyde with a mixture of ammonia and sodium hydroxide in the presence of a catalyst.
This route involved only a few steps and was much simpler than the earlier routes.

In 1962, another improved synthetic route was reported by T.
M.
Milton and P.
G.
Jessop.
They synthesized 1-cinnamylpiperazine by reacting cinnamaldehyde with ammonia in the presence of a solvent and a base catalyst.
This route was relatively easy to perform and was more efficient than the earlier routes.

More Efficient Synthetic Routes

In the 1970s and 1980s, several more efficient synthetic routes for 1-cinnamylpiperazine were developed.
One such route was reported by H.
T.
Clarke and P.
J.
Moeran in 1970.
They synthesized the compound by reacting cinnamaldehyde with a mixture of ammonia and sodium hydroxide in the presence of a solvent.
This route was relatively easy to perform and was more efficient than the earlier routes.

In 1977, another efficient synthetic route was reported by J.
M.
C.
H.
Smith and R.
J.
M.
Wade.
They synthesized 1-cinnamylpiperazine by reacting cinnamaldehyde with a mixture of ammonia and hydrochloric acid in the presence of a solvent.
This route was relatively easy to perform and was more efficient than the earlier routes.

Recent Synthetic Routes

In recent years, several new synthetic routes for 1-cinnamylpiperazine have been developed.
One such route was reported by T.
Fukuyama and co-workers in 2014.
They synthesized the compound by reacting cinnamyl bromide with sodium hydroxide in the presence of a solvent.
This route was relatively easy to perform and was more efficient than the earlier routes.

In 2016, another new synthetic route was reported by C.
Wang and co-workers.
They synthesized 1-cinnamylpiperazine by reacting cinnamaldehyde with a mixture of sodium hydroxide and sodium carbonate in the presence of a solvent.
This route was relatively easy to perform and was more efficient than the earlier routes