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The 1-(6-Chloro-3-pyridazinyl)-4-piperidinol is an important synthetic intermediate in the chemical industry, which is widely used in the production of various pharmaceuticals, agrochemicals, and other industrial chemicals.
The synthesis of 1-(6-Chloro-3-pyridazinyl)-4-piperidinol can be achieved through several different synthetic routes, each with its own advantages and disadvantages.
One of the most commonly used synthetic routes for the synthesis of 1-(6-Chloro-3-pyridazinyl)-4-piperidinol is the via of the Williamson-Etherification reaction.
In this reaction, a primary or secondary alcohol is treated with a chlorinated compound such as 1,2-dichloroethane in the presence of a base such as sodium hydroxide.
The reaction results in the formation of an ether, which is then treated with hydrochloric acid to produce 1-(6-chloro-3-pyridazinyl)-4-piperidinol.
Another commonly used synthetic route for the synthesis of 1-(6-Chloro-3-pyridazinyl)-4-piperidinol is the via of the P2P (phosphorus2phosphorus) reaction.
This reaction is carried out in the presence of a phosphine ligand, such as triphenylphosphine, and a metal catalyst, such as iron powder or zinc chloride.
The reaction results in the formation of 1-(6-chloro-3-pyridazinyl)-4-piperidinol, which can then be isol
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