The Synthetic Routes of 1,4,7-Triazacyclononane

1,4,7-Triazacyclononane is an important organic compound that is widely used in the chemical industry.
It is a synthetic chemical that is used as a building block for the synthesis of various other compounds.
The synthetic routes of 1,4,7-triazacyclononane are many, and they vary depending on the specific application and the desired product.
In this article, we will discuss some of the most commonly used synthetic routes for 1,4,7-triazacyclononane.

One of the most commonly used synthetic routes for 1,4,7-triazacyclononane is the Furan-Reactant Route.
In this route, an alkylating agent such as methyl iodide or ethyl iodide is reacted with furan in the presence of a base such as sodium hydroxide.
The resulting product is then treated with sodium hydride and the alcohol is extracted with ether.
The ether solution is then treated with hydrochloric acid to produce 1,4,7-triazacyclononane.

Another commonly used synthetic route for 1,4,7-triazacyclononane is the Reduction Route.
In this route, 2,4-dinitrochlorobenzene is reduced using a reducing agent such as hydride or dithiopyrithione to produce 1,4,7-triazacyclononane.
This route is especially useful when the furan-reactant route is not feasible due to the availability of the starting materials or the desired product.

A third synthetic route for 1,4,7-triazacyclononane is the Decarboxylation Route.
In this route, the decarboxylation of a derivative of 1,4,7-triazacyclononane is carried out using a reductant such as lithium aluminum hydride or calcium hydride.
This route is useful when the starting material is readily available and the product is easily extracted and purified.

In addition to these synthetic routes, there are several other methods that have been reported in the literature for the synthesis of 1,4,7-triazacyclononane.
These include the use of microwave irradiation, the use of transition metal complexes, and the use of enzymes.

In conclusion, the synthetic routes of 1,4,7-triazacyclononane are many and varied.
Depending on the specific application and the desired product, different synthetic routes can be used.
The three routes discussed in this article, the Furan-Reactant Route, the Reduction Route, and the Decarboxylation Route, are some of the most commonly used methods for the synthesis of 1,4,7-triazacyclononane.
However, other methods have also been reported in the literature, including the use of microwave irradiation, the use of transition metal complexes, and the use of enzymes.