The study revealed the positive regulatory effect of bone marrow fat cells on regeneration after chemotherapy of hematopoietic stem cells

recently, the results of the Zhou Bo Research Group at the Institute of Biochemistry and Cell Biology of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences and the Sean J. Morrison Research Group at the University of Texas Southwestern Medical Center were published online on
. The work revealed the positive regulatory effect of bone marrow fat cells on regeneration after chemotherapy of hematopoietic stem cells, subverting the classical understanding of fat cells as hematopoietic inhibitors in the past.
more than 50 per cent of the adult leg bone is occupied by fat, a proportion that increases further after aging or illness. The number of fat cells in bone marrow is highly related to physiological or pathological bone marrow inhibition. Therefore, fat cell suppression of bone marrow hematosis is used as textbook common sense. Zhou Bo and other work found that bone marrow fat cells can secrete hematopoietic stem cells must grow factor SCF to promote the regeneration of hematopoietic stem cells after chemotherapy. The use of conditional knockout techniques to remove Scf from bone marrow fat cells can lead to defects in the regeneration of hematopoietic stem cells after chemotherapy, which in turn reduces blood oxygen levels and survival rates in mice.Prior work such as
Zhou Bo shows that, under physiological conditions, endothial cells and intervascular periter-filled stem cells are the core parts of the hematopoietic stem cell nest (niche), which promotes the self-renewal of hematopoietic stem cells through structural or functional mechanisms. In the latest study, researchers found that physiological hematopoietic stem cell nests (endothell cells and interstitiotic stem cells) after radiotherapy or chemotherapy were temporarily damaged. In order to maintain the level of SCF in the bone marrow, interstumined stem cells urgently initiate lipid differentiation. Newly generated fat cells become temporary hematopoietic stem cell nests that maintain the body's basic hematopoietic function by secreting stem cell factors such as SCF. After bone marrow reconstruction, the "fat nest" is gradually replaced by the physiological stem cell nest. Therefore, this work reveals the dynamic changes of hematopoietic stem cell nests under stress conditions.
research has been supported by the Leukemia and Lymphoma Society, the HHMI Foundation, and the National Key Laboratory for Cell Biology. (Source: Shanghai Institute of Life Sciences, Chinese Academy of sciences)