The study found that the low molecular weight peptide of red shrimp shrimp head significantly reduced the damage to liver tissue of anti-tumor drugs.

Cyclophosphamide (CTX) is a broad-spectrum anti-tumor drug in which propylene aldehyde swells in the liver and can lead to oxidative stress and inflammatory response in the liver, destroying liver structure and biochemical functionin recent years, naturally sourced functional foods and nutritional supplements have often been used to help maintain human health and reduce organ toxic side effects caused by chemotherapyfoodborne bioactive peptide (Bioactive peptide) has been widely concerned by researchers at home and abroad because of its high digestion, nutrition and physiological effectsSolenocera crassicornis, commonly known as red shrimp, which is mostly processed into shrimp exportsbut accounted for about 40% of the quality of shrimp, shrimp shell and other processing by-products mainly as feed processing raw materials, or as waste treatment, processing value-added is not high, also caused a certain degree of pollution to the environmenttherefore, the scientific development and utilization of shrimp head and other resources to improve its economic value is an urgent problem to be solved, Ding Guofang and Tang Yunping of Zhejiang Ocean University's School of Food and Pharmacology put the degreased shrimp head homogenization, respectively, through gastritas protease and trypsin for progressive enzyme hydrolysis, ultrafiltration to obtain a molecular weight of less than 1 kDa of low molecular weight peptide SCHPs-F1, and SCHPs-F1 molecular weight distribution and amino acid composition of the characterization analysisthe use of SCHPs-F1 to intervene in mice with chemical liver damage caused by CTX, from liver functional markers, histopathology, oxidative stress and inflammatory response biochemical indicators, liver tissue regulation oxidative stress and inflammation-related signaling pathway protein changes, the study of SCHPs-F1 to alleviate the effect of CTX-induced chemical liver damage in micesignificantly lower levels of liver function markers (AST, ALT and AKP) in the group treated with CTX-SCHPs-F1 combination compared to mice treated with CTX, the treatment of SCHPs-F1 significantly restored the cytochrome P450 enzyme content of the mouse liver particulate system caused by CTX, the pathological structural characteristics of liver index abnormalities and multiple liver injuries caused by CTX were also improved under the combination of SCHPs-F1 therapyits mechanism may be SCHPs-F1 on the Nrf2 and NF-B signaling pathway regulation, including effective reduction of the inhibitor protein Keap1, and thus increase the expression of Nrf2 and related downstream antioxidant proteins and antioxidant enzymes, as well as the effective recovery of I-B-alpha to NF-B p65 inhibition, thereby reducing the activation of NF-B p65 and the release of excess inflammatory cell factorslow molecular weight peptide (SCHPs-F1) from Chinese tube-whipped shrimp head showed dose-dependent resanotoxicity in ctX-induced mice, which was reflected in the recovery of liver function markers and pathological structure of liver tissuethe liver protection effect of SCHPs-F1 may be attributed to the dual effects of Nrf2/antioxidants and NF-B/pro-inflammatory cytokine regulatory pathwaysthis study provides a reference for the efficient development and utilization of Chinese tube whip shrimp head and preparation of functionally active peptides with high added value()