The study found that respiratory viruses evade the immune system

U.S. researchers have discovered a mechanism by which common respiratory viruses evade the human immune system and could be used in the future to develop vaccines against common respiratory virus infections.
"human pulmonary virus" is the second most common cause of respiratory infections in children and the elderly worldwide, after another single-stranded RNA virus of the same genus, the respiratory syncytial virus. The study, published February 3 in the British journal Nature Microbiology, showed that the "human pulmonary virus" escapes the attacks of biologically inherent immune responses through a common RNA methylation modification (m6A).
Researchers at Ohio State University in the United States, by tracking cell signals used to produce an inherent immune response, found that the "human pulmonary virus" after methylation modified, successfully reduced the immune protein's ability to recognize viral RNA, thus avoiding the immune system attack.
researchers found that after knocking out this modification, the variant produced by the virus induces a stronger inherent immune response in the body, which is critical to the body's ability to form adaptive immune responses to specific pathogens.
animal experiments with cotton rats by
researchers have shown that the mutated virus can be used as a "human pulmonary virus" vaccine to effectively stop infection in cotton mice, triggering a stronger inherent immune response and an effective adaptive immune response.
researchers say the discovery could also provide clues to the development of "respiratory syncytial viruses" and other viral vaccines, since the methylation modification may also be present in other viruses. (Source: Xinhua News Agency Zhou zhou)
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