The study found that enterobacteria can affect the ability of mosquito-borne viruses to spread
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Last Update: 2020-12-21
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Source: Internet
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Author: User
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recently, Cheng Gong, a researcher at Tsinghua University School of Medicine, found that regulating a mosquito's gut symbox, the mucosal sarepia, can affect the mosquito's ability to transmit the virus. The results were published in Cell-Host and Microbiology.
mosquitoes can carry and transmit hundreds of human viruses. The virus enters the mosquito through the host bloodstream and infects the epithelocytes in its intestines, which in turn spread to the mosquito's salivary glands. "There is a strict correspondence between mosquito-borne viruses and mosquitoes, and the susceptivity of different mosquitoes to the virus is different." Cheng Gong told China Science Daily.
the effects of different intestinal strains, the researchers found that mucous sarepsis significantly increased the susceptivity of the Aedes aegypti mosquito to mosquito-borne viruses. In addition, the levels of this bacteria are also associated with the prevalence of dengue virus, the researchers gave the Aedes aegypti mosquito in the low-risk areas of dengue virus to feed the sticky sarepia, found that the wild Aedes aegypti mosquito is more susceptible to dengue virus.
study further clarified the mechanism by which mucosal sarepia-assisted dengue virus infects the Aedes aegypti mosquito. Through experiments, the researchers found that the protein SmEnhancin secreted by the mucosal sarecella is a key effect molecule in the virus infection process, which degrades the mucous protein layer on the surface of the mosquito's gut cells, thereby increasing the susceptibleness of the intestine cells to the virus.
the first study to discover the role of protein factors encoded by gut bacteria in assisted mosquito-borne virus infections, revealing the interrelations between intestinal symblobacter, mosquito and mosquito-borne viruses. (Source: Ren Fangyan, China Science Journal)
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