The study found that DNA repair was associated with the biological clock

a team at the University of North Carolina School of Medicine found that dna (deoxybonucleic acid) repair in mice was associated with biological clocks. The findings are expected to provide a new basis for adjusting the time cancer patients are given.
study, published in
on July 7, showed that the normal tissue DNA repair capability of mice was most active before and before dusk during the 24-hour biological clock cycle.
led by Nobel Laureate Aziz Sanjar, a senior author of the paper, used the common chemotherapy drug cisplatin to cause DNA damage in mice and observe their self-healing. It was found that the repair of about 2,000 genes (genetically-effected dna fragments) changed over time during the biological clock cycle.
"shunplatin" is a common drug for the treatment of tumors, with strong liver, kidney and nervous system toxicity. Experiments have found that the effects of "shunplatin" on these genes can be divided into two categories: the template chain involved in transcription in the DNA double chain, whose repair is most active before dawn or dusk, and the coding chain that is not involved in transcription, which is most active only before dusk.
these laws associated with the biological clock at the genomic level could help improve cancer therapy, the researchers said. Choosing different times to give the chemotherapy drug "cisplatin" is a viable way to reduce the toxicity of the drug, and this study shows that it should be given when normal cells have the greatest ability to repair DNA. (Source: Xinhua Zhouzhou)