The study found new ways to fight specific tumors.

Recently, Beijing University of Technology Professor Gao Xueyun and the Chinese Academy of Sciences Institute of High Energy Physics Multidisciplinary Research Center researcher Zhao Lina team, completed the copper cluster artificial metalenzyme efficient stabilization of catalytic activity mechanism analysis, and the establishment of artificial metal enzymes targeting cancer cell DNA high-efficiency tumor diagnosis and treatment of new methodsresearch by An artificial metalloenzyme for cancer-specific DNA and operando imaging, published in Science Advances (2020, 6, eabb1421)artificial metal enzymes can achieve a variety of high-efficiency catalytic frontier applications by simulating the structural function of natural metalenzymes, which is an important research areahowever, the catalytic mechanism behind its good functional effects is still unclear, hindering the specific structural design and performance regulation of new artificial metalenzymes in anti-tumor and other applications, which makes the in-depth study of this field face challengesresearchers modified bovine serum albumin with tumor-targeted peptides, and precisely designed the artificial metalenzyme in its inner cavity to construct the active center as a cluster of copper clumpsthrough theoretical calculation and quantitative experimental research, the study shows that the artificial metal enzyme has a substrate-matching energy level and appropriate geometric configuration, which can long-term stable selective catalytic tumor micro-environment overexpression of hydrogen peroxide efficiently converted to hydroxy-based free radicals and oxygenhydroxyl free radicals produced by artificial metalases continuously cut tumor cell DNA for efficient tumor therapy, while long-lasting catalyzing sensitive chemical luminescence can dynamically track the effects of tumor treatment in real time (Figure 1)the study clarifies the fine molecular structure and energy grade distribution characteristics of artificial metal enzymes, and further reveals the catalytic activity mechanism of the enzymeswith the catalytic reaction, the metal valence of the cluster is closed and periodic cycle, ensuring that the active center is not lost, and ensuring the stability and continuity of the catalytic reaction (Figure 2)research provides important guidance for the precise and on-demand synthesis of biocompatible artificial metal enzymes, in addition, it uses the unique catalytic dynamics and stability of metal clusters to construct a new reaction path, establish visual monitoring, efficient new methods against specific tumors()