The study confirmed the new target of analgesy

in the field of pain treatment, traditional opioids have better analgesic effect, but because of their addictive drug abuse has produced serious problems, resulting in huge economic losses, medical burden and social problems. New targets that differ from opioid subjects need to be identified and confirmed to develop new analgesic drugs.
Yang Huaiyu, a professor at the School of Life Sciences of East China Normal University, and Jiang Rutian, a researcher at Huaxi Hospital of Sichuan University, reported on the first TASK-3 potassium ion channel selective excited agent CHET3, based on the small molecule system Evaluating the potential of the TASK-3 channel as a new target, it was found that selective agitation TASK-3 channel can reduce the excitability of injury-causing sensory neurons, thereby suppressing a variety of pain and providing new ideas for the development of new analgesic drugs for non-opioids. The research results were published recently in Science-Translational Medicine.
the small molecules studied in this study played an analgesical effect through the TASK-3 channel of the outer system, thus having an advantage in overcoming central side effects such as addiction. At the same time, the work also revealed that the TASK-3 channel is a new target with new mechanism characteristics, so the drugs targeted at the channel have a biological basis for producing new efficacy. Yang said the team also assessed the potential toxic side effects of the pilot compound CHET3. The current results suggest that the CHET3 system did not cause significant cardiovascular, motor or respiratory disorders in rats, large and small. (Source: Yueyang, China Science Journal)
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