The sociological biology of vascular reconstruction in cardiovascular disease

When hypertension, atherosclerosis, myocardial infarction, and stroke-moderate cardiovascular disease occur, blood vessels under a series of changes, a complex process of change in the balance between the cells and the internal environment called vascular reconstruction (remodeling, reconstruction, remodeling). If the process of vascular reconstruction can be improved, it will help patients maintain vascular stability and help in the treatment of the disease.
factors play a direct and obvious role in vascular reconstruction. Taking vascular reconstruction as the entry point, it is important to clarify the mechanism of mechanobiology, which induces vascular reconstruction to produce biological effects, to find potential drug targets or new biomarkers for the action of vascular factors on blood vessels.
recently, a team from the Institute of Aesthetic Biology (Dr. Han Yue, Dr. Huang Kai, Dr. Yao Qingping and Professor Jiang Zongli) of the School of Life Sciences and Technology of Shanghai Jiaoxuan University published a review paper, "Mechanobibiology in Remodeling", based on their vascular strength in recent years. The new achievements in the study of biological biology are the main line, which introduces the latest research progress in mechanical stress response of vascular cells at home and abroad, the mechanical regulation of vascular mechanical signal transduction networks and non-coding RNA in vascular reconstruction based on high-volume biotechnology, and summarizes some mechanisms of mechanical biology of mechanical factors affecting vascular reconstruction (illustrated).
blood vessel cells, mainly endostrophes and blood vessel smooth muscle cells, can sense various forms of mechanical signals, such as cut stress and strain, and convert them into in-cell biochemic signals, and then through cascading reactions within the cells, and ultimately regulate vascular morphology and function, affecting vascular reconstruction. In addition to chemical factors, interactions between vascular endotrine cells and smooth muscle cells, microbodies in the blood stream, platelets and suspended cells, vascular cellular substrates, and extravascular membranes are also involved in vascular reconstruction.
biomechanics biology is a new interdisciplinary frontier in biomechanics. It studies the mechanism of sensory signals and responses of objects, expounds the relationship between the physical and biological processes, and thus develops new technologies with therapeutic or diagnostic significance and promotes the development of biomedical science. Selecting vascular reconstruction as the starting point and exploring some common and common pathogenesis of cardiovascular disease will be more suitable for the complex characteristics of cardiovascular disease multi-gene and multi-pathogenic factors.
With the progress of modern science and technology, the emergence of new interdisciplinary disciplines has brought new opportunities to explore major scientific problems in the field of life science and health, and new ideas, new technologies and breakthroughs arising from multidisciplinary cross-research are expected to contribute to the effective early warning, diagnosis and prevention of cardiovascular diseases. (Source: Science Network)