The skin hides clues to bowel disease

Photo Source: Cells - Hosts and Microorganisms
Researchers report in Cells - Hosts and Microbes that a fungus commonly found in human hair follicles is also present in the intestines, which can worsen intestinal diseases in patients with a certain genetic structure.
found in oily skin and scalp hair follicles are associated with skin conditions, such as dandruff. These microbes eventually enter the intestines, but it is not clear how they do.
"We were surprised to find that restricting maralas is more common on the surface of the intestinal tissue of patients with Crohn's disease than on the surface of the intestinal tissue of healthy people. "In addition, its presence is associated with a common variant of a gene that is important for fungal immunity -- a trait that is more common in Crohn's patients than in healthy people," said David Underhill of the Center for Inflammatory Bowel Disease in Cedars-Sinai, USA. This
inflammatory bowel disease is characterized by changes in the immune response of the gut microbiome. While most research on the microbiome has focused on bacteria, the Underhill team is looking at the presence of fungi and their potential role in intestinal diseases. Team member Jose Limon, a co-owner of the study, said changes in the gut microbiota and the host's response to those microbes may have been a factor in the worsening of the condition in some patients with Crohn's disease.
researchers initially found that fungi are present in the gut tracts of mice, and that their immunity helps control intestinal inflammation. In mice, limiting the presence of marala bacteria exacerbated colitis.
looked at mucous membrane gut fungi in healthy people and crohn's patients, the researchers found that mucosal-related fungi were significantly more abundant in Crohn's patients. Especially in patients with Crohn's disease, carrying an allele variant called card9 risk of inflammatory bowel disease limits the increase in marala bacteria.
this genetic mutation enhances the ability of human immune cells to pump out inflammatory cytokines in the response to the Marasai bacteria.
"s data so far do not suggest that the intestinal memory of malasella is an inherent bad thing. We also found it in some healthy people. In mice, it doesn't seem to cause intestinal diseases on its own. Underhill said, "However, if there is inflammation of the intestines, marala bacteria seem to make the situation worse." "Next, the researchers plan to eradicate the fungus from the gut bacteria of Crohn's patients to see if they can alleviate symptoms.
crohn's disease is an unexplained inflammatory intestinal disease, there is no cure, many patients have complications, need surgery treatment, and the recurrence rate after surgery is very high. As the course of illness increases and the age increases, the mortality rate increases. Malassy genus, also known asspore genus, fungi are classified as spores, restricting Malasai bacteria is one of them, because of its limited characteristics and named. (Source: Lu Yi, China Science Journal)
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