The scientific research team of Shandong University identified new targets for the treatment of acute kidney injury

team from Shandong University has published new research in an internationally renowned medical journal, confirming for the first time the role of the Gpr97 gene in kidney disease injury. Experts believe that this provides a new genetic target for the future treatment of acute kidney injury.
team is led by Yi Fan, a professor at Shandong University's School of Basic Medicine. The team's paper, "Gpr97 aggravates acute kidney injury by regulating Sema3A signaling pathps," has been published online
. In mouse experiments, the team found that knocking out the Gpr97 gene significantly reduced blood creatinine and urea nitrogen levels in mice with acute kidney injury, improved the degree of renal tube damage, and reduced the immersion of inflammatory cells, thus protecting acute renal injury.
Gpr97 gene belongs to the G protein coupled member family. The latter, consisting of more than 1000 members, is the largest membrane protein family, with a variety of physiological functions such as in-cell signaling, gene transcription, cell recognition and so on. Currently, more than 30% of clinical gene drug targets are located on G protein coupled bodies.
, according to the research team, acute kidney injury is a serious clinical complication, with high morbidity and mortality, but also a major factor leading to end-stage kidney disease. Academic research is gradually revealing the pathological process and pathogenesis of acute kidney injury, but there is still a lack of effective clinical treatment. Finding drug targets for acute kidney injury will help provide new clinical treatment strategies. (Source: Xinhua News Agency, Xiao Haichuan)