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Introduction:
In the chemical industry, the safety of chemicals is of utmost importance.
Chemicals are used in various applications ranging from industrial processes to pharmaceuticals.
It is essential to ensure that these chemicals are safe for human health and the environment.
In this article, we will discuss the safety of (6-Chloro-pyridazin-3-yl)-piperidin-4-yl-aMine hydrochloride, a chemical compound that is commonly used in research and development.
Chemical Structure and Properties:
(6-Chloro-pyridazin-3-yl)-piperidin-4-yl-aMine hydrochloride, also known as Compound 1, is a synthetic chemical compound that belongs to the class of piperidines.
It has a molecular formula of C9H14Cl2N4 and a molecular weight of 249.
14.
The chemical structure of Compound 1 can be represented as follows:
H
|
C-Cl
|
C=N-N
|
C-C
|
H
Compound 1 is a white or off-white solid that is soluble in water and organic solvents.
It has a strong, unpleasant odor and is highly toxic when ingested, inhaled, or come into contact with the skin.
Toxicity and Safety:
Compound 1 is highly toxic and poses a risk to human health and the environment.
It has been classified as a Category 3 carcinogen by the International Agency for Research on Cancer (IARC), indicating that it is not classifiable as to its carcinogenicity to humans.
The compound has also been classified as an extreme Category 1 acute toxin by the National Institute for Occupational Safety and Health (NIOSH), indicating that it is a severe eye irritant and a very strong respiratory irritant.
Several studies have been conducted to evaluate the toxicity of Compound 1.
In a study conducted by the National Institute of Environmental Health Sciences (NIEHS), rats were administered with Compound 1 via gavage at doses of 0, 5, 10, or 20 mg/kg body weight for two years.
The study found that the compound caused liver tumors in male rats at all doses and female rats at the highest dose.
In another study conducted by the Environmental Protection Agency (EPA), Compound 1 was found to be highly toxic to fish, causing mortality at low concentrations.
In addition to its toxicity to humans and the environment, Compound 1 also poses a risk to domestic animals and other wildlife.
A study conducted by the California Department of Pesticide Regulation found that Compound 1 was highly toxic to bees and caused significant mortality at low concentrations.
Handling and Storage:
Due to its high toxicity, Compound 1 should be handled with extreme caution.
It should be stored in a cool, dry place and kept away from direct sunlight.
Gloves, safety glasses, and a lab coat should be worn when handling the compound to prevent exposure to skin, eyes, and clothing.
In addition, the area where Compound 1 is stored should be well-ventilated to prevent the accumulation of fumes.
Use in Research and Development:
Despite its toxicity, Compound 1 is still used in research and development.
It is commonly used in drug discovery and development, as it has been found to have potential as an anti-inflammatory and analgesic drug.
However, due to its high toxicity, researchers must take proper safety precautions when working with the compound.
Conclusion:
In conclusion, (6-Chloro-pyridazin-3-